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Meta-Analysis
. 2020 Aug 10;20(1):294.
doi: 10.1186/s12883-020-01865-3.

Efficacy of adipose derived stem cells on functional and neurological improvement following ischemic stroke: a systematic review and meta-analysis

Mahmoud Yousefifard  1 , Jebreil Shamseddin  2 , Asrin Babahajian  3 , Arash Sarveazad  4   5
Affiliations
Meta-Analysis

Efficacy of adipose derived stem cells on functional and neurological improvement following ischemic stroke: a systematic review and meta-analysis

Mahmoud Yousefifard et al. BMC Neurol. .

Abstract

Background: The evidence on the efficacy of adipose derived stem cells (ADSCs) in the treatment of stroke is controversial. Therefore, the aim of present systematic review and meta-analysis is to evaluate the efficacy of ADSCs administration in the treatment of animal models of ischemic stroke.

Methods: An extensive search was performed on electronic databases of Medline, Embase, Scopus, CENTRAL and Web of Science until December 31, 2018. Animal studies that used ADSCs in treatment of ischemic stroke were included. The data were recorded as mean and standard deviation and then a pooled standardized mean difference (SMD) with 95% confidence interval (95% CI) was reported.

Results: Twenty articles were included in the present meta-analysis. It was observed that administration of ADSCs improves motor function (SMD = 2.52, 95% CI: 1.67 to 3.37, p < 0.0001) and neurological status (SMD = 2.05, 95% CI: 1.33 to 2.78, p < 0.0001) in animals following an ischemic stroke. Multivariate meta-regression showed the model of stroke induction (p = 0.017) and the number of transplanted cells (p = 0.007) affect the efficacy of ADSCs administration on motor function improvement following the stroke.

Conclusion: Moderate to high levels of evidence indicate a strong efficacy of ADSCs transplantation on motor function and neurological improvement following ischemic stroke in animal models. However, no reports regarding the dose-response effect of ADSCs administration on stroke exist in the literature. As a result, further pre-clinical studies are recommended to be conducted on the matter.

Keywords: Functional recovery; Stem cells; Stroke.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
PRISMA flow diagram of the present meta-analysis
Fig. 2
Fig. 2
Methodological assessment of included studies (a) and risk of bias in evaluation of motor function recovery (b) and neurological status (c)
Fig. 3
Fig. 3
Forest plot of motor function recovery after ADSCs in ischemic stroke. SMD: standardized mean difference; CI: Confidence interval. Gutiérrez-Fernandez et al. 2015, compared xenogeneic and allogeneic adipose mesenchymal stem cells in the treatment of acute stroke. Therefore, two separate experiment were included in the meta-analysis
Fig. 4
Fig. 4
Forest plot of neurological recovery after ADSCs in ischemic stroke. SMD: standardized mean difference; CI: Confidence interval
See this image and copyright information in PMC

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