Substantial Cellular Penetration of Fluorescent Imidazoquinoxalines

Abstract

Fluorescent tools have revolutionized our capability to visualize, probe, study, and understand the biological cellular properties, processes and dynamics, enabling researchers to improve their knowledge for example in cancer field. In this paper, we use the peculiar properties of our Imiqualines derivatives to study their cellular penetration and distribution in a human melanoma cell line A375 using confocal microscopy. Preliminary results on colocalization with the potent protein target c-Kit of our lead are also described.

Keywords: A375 cells.; Confocal microscopy; Fluorescence; Imidazo[1,2-a]quinoxaline; Localization; Melanoma.