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Review
. 2021 May:68 Suppl 2:e28352.
doi: 10.1002/pbc.28352. Epub 2020 Aug 11.

Osteosarcoma

Bree R Eaton  1 , Rudolf Schwarz  2 , Ralph Vatner  3 , Brian Yeh  4 , Line Claude  5 , Daniel J Indelicato  6 , Nadia Laack  7
Affiliations
Review

Osteosarcoma

Bree R Eaton et al. Pediatr Blood Cancer. 2021 May.

Abstract

Osteosarcoma is a rare tumor that requires complex multidisciplinary management. This paper reviews the general management and standard radiotherapy guidelines for osteosarcoma in both North America and Europe in a joined effort between the Children's Oncology Group and International Society of Pediatric Oncology. Standard treatment involves multiagent induction chemotherapy followed by surgical resection for local tumor control and consolidation local control to metastatic sites. Radiotherapy is reserved for cases with a marginal or incomplete resection or for definitive treatment in the case of unresectable disease. We present supporting data for the role of chemotherapy, surgery, and radiation therapy.

Keywords: chemotherapy; metastasis; osteosarcoma; radiotherapy; surgery.

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References

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