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. 2020 Dec;30(6):1523-1530.
doi: 10.1007/s10895-020-02605-z. Epub 2020 Aug 11.

Florescence Imaging Lung Cancer with a Small Molecule MHI-148

Xiaotian Xia  1   2 , Yongkang Gai  1   2 , Hongyan Feng  1   2 , Chunxia Qin  1   2 , Dongfeng Pan  3 , Yiling Song  1   2 , Yongxue Zhang  1   2 , Xiaoli Lan  4   5
Affiliations

Florescence Imaging Lung Cancer with a Small Molecule MHI-148

Xiaotian Xia et al. J Fluoresc. 2020 Dec.

Abstract

MHI-148 is a type of heptamethine cyanine dye that can cross the cytoplasmic membrane of lung cancer cells. Here we tested the cytotoxic, in vivo imaging of MHI-148 in lung-cancer nude mice model. Ex vivo imaging was also been measured by testing the major tissue fluorescence intensity. And, the small molecular compound MHI-148 had low cytotoxicity which could be visualized at 1 h post-injection in tumor. From ex vivo fluorescence imaging, the tumor showed the highest uptake of MHI-148 among all the selected organs expect for the time point of 2 h. MHI-148 could be used for effective imaging in lung cancer tissue with good stability and specificity, which suggested that MHI-148 could be an effective tumor clinical imaging agent.

Keywords: Lung cancer; MHI-148; Near infrared fluorescence imaging; Organic anion transporting polypeptide.

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