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Review
. 2020 Sep;9(5):405-414.
doi: 10.1016/j.jshs.2020.03.004. Epub 2020 Mar 19.

The roles of microRNA in redox metabolism and exercise-mediated adaptation

Ferenc Torma  1 , Zoltan Gombos  1 , Matyas Jokai  1 , Istvan Berkes  1 , Masaki Takeda  2 , Tatsuya Mimura  3 , Zsolt Radak  4 , Ferenc Gyori  5
Affiliations
Review

The roles of microRNA in redox metabolism and exercise-mediated adaptation

Ferenc Torma et al. J Sport Health Sci. 2020 Sep.

Abstract

MicroRNAs (miRs) are small regulatory RNA transcripts capable of post-transcriptional silencing of mRNA messages by entering a cellular bimolecular apparatus called RNA-induced silencing complex. miRs are involved in the regulation of cellular processes producing, eliminating or repairing the damage caused by reactive oxygen species, and they are active players in redox homeostasis. Increased mitochondrial biogenesis, function and hypertrophy of skeletal muscle are important adaptive responses to regular exercise. In the present review, we highlight some of the redox-sensitive regulatory roles of miRs.

Keywords: Adaptation; Exercise; MicroRNA; Oxidative damage; Reactive oxygen species; Redox regulation.

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Figures

Image, graphical abstract
Graphical abstract
Fig 1
Fig. 1
The tissue specificity of miR production. MicroRNAs have complex regulatory roles but show tissue specificity as well. miR = microRNA; ROS = reactive oxygen species.
Fig 2
Fig. 2
MicroRNA-mediated regulation of NFE2L2, PGC-1α, and HIF-1α. The suggested microRNA-associated regulation of 3 important signaling proteins in the cell. HIF-1α = hypoxia-inducable factor 1-α;  NFE2L2 = nuclear factor erythroid 2-related factor 2; PGC-1α = peroxisome proliferator-activated receptor gamma coactivator 1-α; UTR = untranslated region; p = point mutation.
See this image and copyright information in PMC

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