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Review
. 2021 Mar 26;27(18):5577-5600.
doi: 10.1002/chem.202002887. Epub 2021 Jan 31.

Cannabidiol Discovery and Synthesis-a Target-Oriented Analysis in Drug Production Processes

Anderson R Aguillón  1 , Raquel A C Leão  1   2 , Leandro S M Miranda  1 , Rodrigo O M A de Souza  1   2
Affiliations
Review

Cannabidiol Discovery and Synthesis-a Target-Oriented Analysis in Drug Production Processes

Anderson R Aguillón et al. Chemistry. .

Abstract

The current state of evidence and recommendations for cannabidiol (CBD) and its health effects change the legal landscape and aim to destigmatize its phytotherapeutic research. Recently, some countries have included CBD as an antiepileptic product for compassionate use in children with refractory epilepsy. The growing demand for CBD has led to the need for high-purity cannabinoids on the emerging market. The discovery and development of approaches toward CBD synthesis have arisen from the successful extraction of Cannabis plants for cannabinoid fermentation in brewer's yeast. To understand different contributions to the design and enhancement of the synthesis of CBD and its key intermediates, a detailed analysis of the history behind cannabinoid compounds and their optimization is provided herein.

Keywords: cannabinoids; drug discovery; natural products; phytotherapeutic research; synthesis design.

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References

    1. R. Mechoulam, L. Hanuš, Chem. Phys. Lipids 2000, 108, 1-13.
    1. B. Warf, Geogr. Rev. 2014, 104, 414-438.
    1. E. B. Russo, Chem. Biodiversity 2007, 4, 1614-1648.
    1. R. J. Bonnie, C. H. Whitebread II, The Marijuana Conviction: A History of Marijuana Prohibition in the United States, Lindesmith Center, New York, 1999.
    1. T. A. Reekie, M. P. Scott, M. Kassiou, Nat. Rev. Chem. 2018, 2.

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