Clinical and demographic characteristics of adenomatoid odontogenic tumors: analysis of 116 new cases from a single center

Abstract

Introduction: The adenomatoid odontogenic tumor is a relatively uncommon odontogenic neoplasm representing about 4.7% of all odontogenic tumors.

Objective: The aim of this study was to determine the demographic and clinical profile of the adenomatoid odontogenic tumors in a Sri Lankan population.

Methods: Data gathered from the cases received for a period of 38 years from the Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya. Request forms, biopsy reports and electronic data base of the department were used to obtain relevant information. Demographic data including age, gender and location of the tumor were included in the analysis.

Results: Out of 116 cases of adenomatoid odontogenic tumor, the mean age was 21.02 ± 11.24. It occurs more fre quently in the second decade of life, more prevalent in females, most often associated with the maxilla, predominantly affecting anterior jaw bones and presenting mostly in the right side of the jaw bone. The results from the present study showed the statistically significant relationship with site of occurrence (maxilla/mandible) and age (p < 0.005). Further, depending on whether it occurs in anterior/mid/posterior site also showed a significant relationship with age (p ≤ 0.001). However, side of occurrence, left or right or site of occurrence, showed no statistically significance with age (p > 0.05).

Conclusion: Adenomatoid odontogenic tumor occurs more frequently in the second decade of life with a significant female predominance and the commonest site is anterior maxilla. This study revealed few differences on demographic and clinical presentations of adenomatoid odontogenic tumor from some regions of the world.

Keywords: AOT; Adenomatoid odontogenic tumors; Demography; Odontogenic tumors; Relative frequency.

Figure 1

(A) Distribution of AOT among age groups. (B) Distribution of cases within the 11−20 age group.

Figure 2

Distribution of AOT cases within jaw bones. Ant, Anterior; Mid, Middle; Post, Posterior.

Figure 3

(A) Histological appearance of AOT. (B) AOT with numerous calcifications. (C) AOT with eosinophilic material mimicking dentin (asterisk) higher magnification.