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Case Reports
. 2020 Aug 6;2020(8):rjaa255.
doi: 10.1093/jscr/rjaa255. eCollection 2020 Aug.

A maxillary ameloblastic fibrosarcoma tumor: a rare case report from Syria

Amjad Soltany  1   2 , Ghazal Asaad  2   3 , Rami Daher  2   3 , Mouhannad Dayoub  2   4 , Ali Khalil  5 , Zuheir Alshehabi  2   6
Affiliations
Case Reports

A maxillary ameloblastic fibrosarcoma tumor: a rare case report from Syria

Amjad Soltany et al. J Surg Case Rep. .

Abstract

Ameloblastic fibrosarcoma (AFS) is a rare, aggressive malignant odontogenic tumor. AFS is seen most frequently in second and third decades of life. We are reporting a case of a low grade AFS in a 21-year-old male complaining of a painless swelling in the right side of the maxilla. The patient was treated with surgical excision followed by radiotherapy, which is considered the most effective approach for most of soft tissue sarcomas. AFS has a high-reported recurrence rate (up to 37%); therefore, long-term surveillance for recurrence is crucial.

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Figures

Figure 1
Figure 1
Clinical appearance of the tumor at the time of diagnosis, showing a swelling in the palatine process of maxilla, spreading from the vestibule of the mouth reaching the upper right premolars.
Figure 2
Figure 2
Preoperative orthopantomogram shows the radiolucent area with the calcified lesions in the right hemi-maxilla with resorption in the roots of the upper right premolars.
Figure 3
Figure 3
Biphasic tumor composed of islands of benign odontogenic epithelium and an abundant malignant mesenchymal component consisted of ovoid and fusiform cells, in addition to plump and spindle stromal cells that show hyper-cellularity and nuclear polymorphisms associated with cytologic atypia, mitotic figures and anaplasia (hematoxylin-eosin,x40).
Figure 4
Figure 4
Reactivity to immuno-histochemical stains shows: A: positive reactivity to Vimentin in the mesenchymal component. B: negative reactivity to P53. C: negative reactivity to Bcl2. D: Reactivity to Ki67 in the mesenchymal component with a labeling index of 10–15%.
Figure 5
Figure 5
The excised specimen showing an irregularly shaped yellowish graymass.
See this image and copyright information in PMC

References

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