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. 2021 Feb;85(2):615-626.
doi: 10.1002/mrm.28453. Epub 2020 Aug 11.

Estimating vertebral bone marrow fat unsaturation based on short-TE STEAM MRS

Jan Syväri  1 , Stefan Ruschke  1 , Michael Dieckmeyer  1 , Hans H Hauner  2 , Daniela Junker  1 , Marcus R Makowski  1 , Thomas Baum  3 , Dimitrios C Karampinos  1
Affiliations

Estimating vertebral bone marrow fat unsaturation based on short-TE STEAM MRS

Jan Syväri et al. Magn Reson Med. 2021 Feb.

Abstract

Purpose: To define a metric for the separability between water and olefinic fat peaks that defines a threshold beyond which the extraction of the olefinic fat peak from vertebral bone marrow short-echo time-stimulated echo acquisition mode MRS at 3T is feasible when using a constrained peak fitting based on the triglyceride fat model.

Methods: The water and olefinic peak height difference was defined as a metric for quantifying the separability of water and olefinic fat peaks. Fat unsaturation was determined using an unconstrained olefinic peak fitting and a constrained fitting of all fat peaks to the triglyceride model. The agreement between the two peak-fitting methods was used to define a threshold on water and olefinic peak height difference separating two groups (A and B), based on L5 short-echo time-stimulated echo acquisition mode (TE = 11 ms) spectra from 252 subjects measured at 3T.

Results: A threshold on water and olefinic peak height difference was defined. Group A with a good agreement of the olefinic fat peak between the two peak-fitting methods showed a mean number of double bounds = 2.95 ± 0.21, a mean number of methylene-interrupted double bounds = 0.94 ± 0.16 and also a significantly lower coefficient of variation for all fatty acid composition parameters compared to group B (p < .001). The water and olefinic peak height difference value showed an inverse association with fat fraction.

Conclusion: A threshold of a metric quantifying the separability of the water peak and the olefinic fat peaks was defined for the estimation of the vertebral bone marrow fat unsaturation from short-echo time-stimulated echo acquisition mode MRS. The proposed methodology shows that the assessment of vertebral bone marrow unsaturation is feasible with a short-echo time-stimulated echo acquisition mode MRS in subjects with a higher fat fraction.

Keywords: bone marrow; fat unsaturation; single-voxel magnetic resonance spectroscopy; triglyceride model.

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References

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