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Review
. 2020 Oct 1;319(4):C624-C629.
doi: 10.1152/ajpcell.00303.2020. Epub 2020 Aug 12.

miRNA degradation in the mammalian brain

Chun K Kim  1 , Toni R Pak  1
Affiliations
Review

miRNA degradation in the mammalian brain

Chun K Kim et al. Am J Physiol Cell Physiol. .

Abstract

MicroRNAs (miRNAs) are short, noncoding RNAs that are evolutionarily conserved across many different species. miRNA regulation of gene expression, specifically in the context of the mammalian brain, has been well characterized; however, the regulation of miRNA degradation is still a focus of ongoing research. This review focuses on recent findings concerning the cellular mechanisms that govern miRNA degradation, with an emphasis on target-mediated miRNA degradation and how this phenomenon is uniquely poised to maintain homeostasis in neuronal systems.

Keywords: TDMD; brain; degradation; microRNA; stability.

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Conflict of interest statement

No conflicts of interest, financial or otherwise, are declared by the authors.

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