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Case Reports
. 2020 Oct;103(4):1350-1351.
doi: 10.4269/ajtmh.20-0721.

Peripheral Blood Smear Demonstration of Lymphocyte Changes in Severe COVID-19

Chun-Tsu Lee  1   2   3   4 , Winnie Z Y Teo  1   2   3
Affiliations
Case Reports

Peripheral Blood Smear Demonstration of Lymphocyte Changes in Severe COVID-19

Chun-Tsu Lee et al. Am J Trop Med Hyg. 2020 Oct.
No abstract available

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Figures

Figure 1.
Figure 1.
(A) Peripheral blood smear revealed a normal resting lymphocyte from healthy individual (Wright–Giemsa staining; viewed under oil immersion lens at ×1,000 magnification). (B and C) Peripheral blood smears from a patient with severe COVID-19 revealed an enlarged reactive lymphocyte with dark basophilic cytoplasms with peripheral accentuation, eccentric round or indented nucleus with dense chromatin, and perinuclear Hof. They have copious cytoplasms that scallop around adjacent red blood cells. They are generally seen in viral infections such as dengue fever, and infectious mononucleosis. (D) This is a Mott cell, a variant of plasma cell with immunoglobulin entrapped in the endoplasmic reticulum, in a form of Russell bodies (Wright–Giemsa staining; viewed under oil immersion lens at ×1,000 magnification).
See this image and copyright information in PMC

References

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