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Comment
. 2020 Aug 1;319(2):E455-E457.
doi: 10.1152/ajpendo.00348.2020.

Reply to Jakovac and to Rocha et al.: Can vitamin D prevent or manage COVID-19 illness?

Andrzej T Slominski  1   2 , Radomir M Slominski  3   4 , Paul A Goepfert  3   5 , Tae-Kang Kim  1 , Michael F Holick  6 , Anton M Jetten  7 , Chander Raman  3   4
Affiliations
Comment

Reply to Jakovac and to Rocha et al.: Can vitamin D prevent or manage COVID-19 illness?

Andrzej T Slominski et al. Am J Physiol Endocrinol Metab. .
No abstract available

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Conflict of interest statement

Michael F. Holick is on the Speakers Bureau for Abbott, former consultant for Quest diagnostics, and a consultant Ontometrics Inc. None of the other authors has any conflicts of interest, financial or otherwise, to disclose.

Figures

Fig. 1.
Fig. 1.
Active forms of vitamin D3 by counteracting cytokine storm and oxidative stress will attenuate acute respiratory distress syndrome (ARDS) secondary to coronavirus disease. Arabic numbers, positions of hydroxyl groups on vitamin D3; n, number of hydroxyl groups; CYP11A1, CYP2R1, and CYP27B1, enzymes hydroxylating vitamin D3 with CYP2R1 hydroxylating at C25 and CYP 27B1 hydroxylating 25(OH)D3 at C1α to generate 1,25(OH)2D3 (calcitriol); SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
See this image and copyright information in PMC

Comment on

References

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    1. Holick MF. Vitamin D deficiency. N Engl J Med 357: 266–281, 2007. doi:10.1056/NEJMra070553. - DOI - PubMed
    1. Ilie PC, Stefanescu S, Smith L. The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality. Aging Clin Exp Res 32: 1195–1198, 2020. doi:10.1007/s40520-020-01570-8. - DOI - PMC - PubMed
    1. Jakovac H. COVID-19 and vitamin D-Is there a link and an opportunity for intervention? Am J Physiol Endocrinol Metab 318: E589, 2020. doi:10.1152/ajpendo.00138.2020. - DOI - PMC - PubMed
    1. Jetten AM, Cook DN. (Inverse) agonists of retinoic acid-related orphan receptor γ: regulation of immune responses, inflammation, and autoimmune disease. Annu Rev Pharmacol Toxicol 60: 371–390, 2020. doi:10.1146/annurev-pharmtox-010919-023711. - DOI - PMC - PubMed