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. 2021 Mar;41(3):460-467.
doi: 10.1038/s41372-020-00774-0. Epub 2020 Aug 12.

The association between preeclampsia and ICD diagnosis of neonatal sepsis

Rachel K Harrison  1 , Anna Palatnik  2   3
Affiliations

The association between preeclampsia and ICD diagnosis of neonatal sepsis

Rachel K Harrison et al. J Perinatol. 2021 Mar.

Abstract

Objective: Infants born to mothers with preeclampsia are at risk for many short and long-term complications. The objective of this study was to examine the association between preeclampsia and ICD diagnosis of neonatal sepsis in a large United States data set.

Study design: A retrospective cohort study from the Consortium on Safe Labor. A total of 180,277 women with a singleton gestation greater than 23 weeks were included. The primary outcome, neonatal sepsis, was compared between women stratified by diagnosis of preeclampsia using univariable and multivariable analyses.

Results: Of the 180,277 women eligible for analysis, 8331 (4.6%) were diagnosed with preeclampsia. Neonatal sepsis rates were higher among women diagnosed with preeclampsia (6.4 vs. 2.0%, p < 0.001). In multivariable logistic regression, adjusted for confounders, the association between preeclampsia and neonatal sepsis remained significant (adjusted OR = 1.30, 95% CI: 1.06-1.60).

Conclusion: In this large cohort, the rate of neonatal sepsis ICD diagnosis was higher among women diagnosed with preeclampsia.

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