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. 2020 Jul 19;17(13):1864-1870.
doi: 10.7150/ijms.44443. eCollection 2020.

Resveratrol reduces inflammation-related Prostate Fibrosis

Enzo Vicari  1 , Alessandro Arancio  1 , Vito Emanuele Catania  2 , Beatrice Ornella Vicari  3 , Giuseppe Sidoti  4 , Roberto Castiglione  1 , Michele Malaguarnera  3
Affiliations

Resveratrol reduces inflammation-related Prostate Fibrosis

Enzo Vicari et al. Int J Med Sci. .

Abstract

Inflammation-related prostate fibrosis (PF) is strongly associated with impaired urethral function and lower urinary tract symptoms (LUTS) severity. The aim of this study was to investigate the effects of RSV in patients with small prostate volume and LUTS. Sixty-four patients with PF were randomized either to RSV therapy (group A= 32 patients) or placebo (group B= 32 patients). At baseline (T0) and after 2-months (T2), patients of both groups underwent administration of NIH-Chronic Prostatic Symptom Index (NIH-CPSI) and International Prostate Symptom Score (IPSS) questionnaires for prostatitis and LUTS, respectively, and Expressed Prostatic Secretion (EPS) assays. After two months, only, group A patients treated with RSV showed significant symptomatic improvement of all NIH-CPSI and IPSS subscale scores, as well as a better EPS assay after prostate massage, in terms of high amount of prostatic volume and reduced white blood cells counts. Our data suggested pharmacological advantage after 2-month treatment with RSV in selected patients with PF for the treatment of voiding and storage complaints.

Keywords: IPSS; LUTS; Meares and Stamey test; NIH-CPSI; Prostate fibrosis; Resveratrol; small prostate volume.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

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