Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2020 Dec;183(6):1145-1147.
doi: 10.1111/bjd.19484. Epub 2020 Sep 24.

Co-reactivation of the human herpesvirus alpha subfamily (herpes simplex virus-1 and varicella zoster virus) in a critically ill patient with COVID-19

Affiliations
Case Reports

Co-reactivation of the human herpesvirus alpha subfamily (herpes simplex virus-1 and varicella zoster virus) in a critically ill patient with COVID-19

R Xu et al. Br J Dermatol. 2020 Dec.

Erratum in

  • Corrigendum.
    [No authors listed] [No authors listed] Br J Dermatol. 2021 Sep;185(3):685. doi: 10.1111/bjd.20561. Br J Dermatol. 2021. PMID: 34472637 Free PMC article. No abstract available.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
(a) Next‐generation sequencing tests of pathogen from blood and deep sputum or bronchoalveolar lavage fluid (BAFL) samples. Viraemia [varicella zoster virus (VZV) and herpes simplex virus (HSV)‐1] and BAFL (HSV‐1) were detected on 8 March 2020 (N, not detected; red, high; pink, low), which might have resulted in aggravation of the disease course. The symptoms and laboratory indicators both improved after acyclovir treatment. (b) Clinical manifestation of herpes zoster. (c) Several small ulcers on the bronchial mucosa during the fibre optic bronchoscopy. VV‐ECMO, venovenous extracorporeal membrane oxygenation.

References

    1. Zhang JJ, Dong X, Cao YY et al. Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China. Allergy 2020; 75:1730–41. - PubMed
    1. Ouwendijk WJ, Laing KJ, Verjans GM, Koelle DM. T‐cell immunity to human alphaherpesviruses. Curr Opin Virol 2013; 3:452–60. - PMC - PubMed
    1. Mitchell BM, Bloom DC, Cohrs RJ et al. Herpes simplex virus‐1 and varicella‐zoster virus latency in ganglia. J Neurovirol 2003; 9:194–204. - PubMed
    1. Chen G, Wu D, Guo W et al. Clinical and immunologic features in severe and moderate coronavirus disease 2019. J Clin Invest 2020; 130:2620–9. - PMC - PubMed
    1. Zheng M, Gao Y, Wang G et al. Functional exhaustion of antiviral lymphocytes in COVID‐19 patients. Cell Mol Immunol 2020; 17:533–5. - PMC - PubMed