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Review
. 2020 Oct;52(9):e13791.
doi: 10.1111/and.13791. Epub 2020 Aug 13.

Impact of COVID-19 and other viruses on reproductive health

Osamah Batiha  1 , Taghleb Al-Deeb  2 , Esra'a Al-Zoubi  1 , Emad Alsharu  3
Affiliations
Review

Impact of COVID-19 and other viruses on reproductive health

Osamah Batiha et al. Andrologia. 2020 Oct.

Abstract

Male infertility is linked to some viral infections including human papillomavirus (HPV), herpes simplex viruses (HSV) and human immunodeficiency viruses (HIVs). Almost nothing is known about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) effect on fertility. The possible risk factors of coronavirus disease 2019 (COVID-19) infection on fertility comes from the abundance of angiotensin-Converting Enzyme-2 (ACE2), receptor entry of the virus, on testes, a reduction in important sex hormone ratios and COVID-19-associated fever. Recent studies have shown a gender difference for COVID-19 rates and comorbidity. In this review, we will discuss the potential effect of COVID-19 on male fertility and talk about what needs to be done by the scientific community to tackle our limited understanding of the disease. On the other side, we will focus on what is known so far about the risk of COVID-19 on pregnancy, neonatal health and the vertical transfer of the virus between mothers and their neonates. Finally, because reproduction is a human right and infertility is considered a health disease, we will discuss how assisted reproductive clinics can cope with the pandemic and what guidelines they should follow to minimise the risk of viral transmission.

Keywords: COVID-19; SARS-CoV-2; assisted reproductive technologies; infertility; reproduction.

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Figures

FIGURE 1
FIGURE 1
Infection cycle of SARS‐CoV2. Please refer to the text for more description
See this image and copyright information in PMC

References

    1. Adhikari, S. P. , Meng, S. , Wu, Y.‐J. , Mao, Y.‐P. , Ye, R.‐X. , Wang, Q.‐Z. , … Zhou, H. (2020). Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID‐19) during the early outbreak period: A scoping review. Infectious Diseases of Poverty, 9(1), 1–12. 10.1186/s40249-020-00646-x - DOI - PMC - PubMed
    1. Aiman, J. , Brenner, P. F. , & Macdonald, P. C. (1980). Androgen and estrogen production in elderly men with gynecomastia and testicular atrophy after mumps orchitis*. Journal of Clinical Endocrinology and Metabolism, 50(2), 380–386. 10.1210/jcem-50-2-380 - DOI - PubMed
    1. Alanagreh, L. , Alzoughool, F. , & Atoum, M. (2020). Risk of using hydroxychloroquine as a treatment of COVID‐19. International Journal of Risk & Safety in Medicine, 1–6. 10.3233/jrs-200024 - DOI - PMC - PubMed
    1. Amirjannati, N. , Yaghmaei, F. , Mehdi Akhondi, M. , Nasiri, M. , Heidari‐Vala, H. , & Sehhat, Z. (2014). Molecular and serologic diagnostic approaches; the prevalence of herpes simplex in idiopathic men infertile. Iran Journal of Reproductive Medicine, 12. - PMC - PubMed
    1. ASRM . (n.d.). AMERICAN SOCIETY FOR REPRODUCTIVE MEDICINE (ASRM) PATIENT MANAGEMENT AND CLINICAL RECOMMENDATIONS DURING THE CORONAVIRUS (COVID‐19) PANDEMIC Update #3. Retrieved from https://www.asrm.org/news‐and‐publications/covid‐19/statements/patient‐m...

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