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Clinical Trial
. 1988 Mar;49(3):113-6.

Plasma levels and therapeutic response with trimipramine treatment of endogenous depression

G M Simpson  1 , E H Pi, L Gross, D Baron, M November
Affiliations
  • PMID: 3279023
Clinical Trial

Plasma levels and therapeutic response with trimipramine treatment of endogenous depression

G M Simpson et al. J Clin Psychiatry. 1988 Mar.

Abstract

In a 6-week, double-blind study involving 34 endogenously depressed patients, plasma trimipramine levels of two dosage groups, 75-mg/day and 150-mg/day, were compared with regard to clinical efficacy as determined by scores on the Hamilton Rating Scale for Depression, the Clinical Global Impressions scale, and the Zung Self-Rating Depression Scale. Both dosage levels of trimipramine produced prompt, consistent, and progressive antidepressant effects. No correlation between plasma levels and clinical efficacy was found.

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