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Comment
. 2020 Sep 15;39(18):e106305.
doi: 10.15252/embj.2020106305. Epub 2020 Aug 13.

A Timeless Tale: G4 structure recognition by the fork protection complex triggers unwinding by DDX11 helicase

Catherine H Freudenreich  1
Affiliations
Comment

A Timeless Tale: G4 structure recognition by the fork protection complex triggers unwinding by DDX11 helicase

Catherine H Freudenreich. EMBO J. .

Abstract

How the replisome senses and deals with DNA secondary structures has been a mystery. A new study from the Sale and Pellegrini laboratories finds that the Timeless protein has a G-quadruplex binding domain that works together with the DDX11 helicase to facilitate replication of G4 DNA structures.

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Figures

Figure 1
Figure 1. A model for how Timeless could detect G4 DNA motifs
(A) Situation where a preformed G4 is encountered by the replisome and the CMG (Cdc45‐MCM‐GINS) helicase. (B) Situation where the G4 forms after CMG‐mediated strand unwinding. In each case, Timeless recruits DDX11 for G4 unwinding. See text for details.
See this image and copyright information in PMC

Comment on

References

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