Urine: A Lens for Asthma Pathogenesis and Treatment?

Affiliations

Editorial

R Stokes Peebles Jr. Am J Respir Crit Care Med. 2021.

. 2021 Jan 1;203(1):1-3.

doi: 10.1164/rccm.202007-2899ED.

¹ Department of Medicine Vanderbilt University School of Medicine Nashville, Tennessee.

No abstract available

Figures

Urinary Leukotriene E₄ and Prostaglandin D₂ Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study.
Kolmert J, Gómez C, Balgoma D, Sjödin M, Bood J, Konradsen JR, Ericsson M, Thörngren JO, James A, Mikus M, Sousa AR, Riley JH, Bates S, Bakke PS, Pandis I, Caruso M, Chanez P, Fowler SJ, Geiser T, Howarth P, Horváth I, Krug N, Montuschi P, Sanak M, Behndig A, Shaw DE, Knowles RG, Holweg CTJ, Wheelock ÅM, Dahlén B, Nordlund B, Alving K, Hedlin G, Chung KF, Adcock IM, Sterk PJ, Djukanovic R, Dahlén SE, Wheelock CE; U-BIOPRED Study Group, on behalf of the U-BIOPRED Study Group. Kolmert J, et al. Am J Respir Crit Care Med. 2021 Jan 1;203(1):37-53. doi: 10.1164/rccm.201909-1869OC. Am J Respir Crit Care Med. 2021. PMID: 32667261 Free PMC article.

1. Kolmert J, Gómez C, Balgoma D, Sjödin M, Bood J, Konradsen JR, et al. U-BIOPRED Study Group. Urinary leukotriene E4 and prostaglandin D2 metabolites increase in adult and childhood severe asthma characterized by type 2 inflammation: a clinical observational study. Am J Respir Crit Care Med. 2021;203:37–53. - PMC - PubMed
1. Peebles RS., Jr Prostaglandins in asthma and allergic diseases. Pharmacol Ther. 2019;193:1–19. - PMC - PubMed
1. MacGlashan DW, Jr, Schleimer RP, Peters SP, Schulman ES, Adams GK, III, Newball HH, et al. Generation of leukotrienes by purified human lung mast cells. J Clin Invest. 1982;70:747–751. - PMC - PubMed
1. Jörg A, Henderson WR, Murphy RC, Klebanoff SJ. Leukotriene generation by eosinophils. J Exp Med. 1982;155:390–402. - PMC - PubMed
1. Örning L, Kaijser L, Hammarström S. In vivo metabolism of leukotriene C4 in man: urinary excretion of leukotriene E4. Biochem Biophys Res Commun. 1985;130:214–220. - PubMed