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. 1977 Jun;11(6):968-73.
doi: 10.1128/AAC.11.6.968.

Inhibition of amino acid transport in Escherichia coli by some beta-lactam antibiotics

Inhibition of amino acid transport in Escherichia coli by some beta-lactam antibiotics

S V Anderson et al. Antimicrob Agents Chemother. 1977 Jun.

Abstract

Among 10 antibiotics tested, cephaloridine and cephalothin showed the greatest inhibition of proline active transport. Ethylenediaminetetraacetate pretreatment of the cells did not enhance inhibition by any of these 10 antibiotics. The inhibition of active transport of 10 additional amino acids by cephaloridine and cephalothin was studied. Both antibiotics inhibited transport of three amino acids which, like proline, have transport systems resistant to osmotic shock; neither antibiotic inhibited transport of the remaining amino acids, including three with shock-resistant and four with shock-sensitive systems.

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References

    1. Bacteriol Rev. 1962 Sep;26:292-335 - PubMed
    1. Proc Natl Acad Sci U S A. 1966 Apr;55(4):920-7 - PubMed
    1. J Biol Chem. 1965 Sep;240(9):3685-92 - PubMed
    1. Ann N Y Acad Sci. 1974 May 10;235(0):519-41 - PubMed
    1. Ann N Y Acad Sci. 1974 May 10;235(0):569-86 - PubMed

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