Commentary: Amhr2-Cre-Mediated Global Tspo Knockout

Affiliations

¹ Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY, United States.
² Division of Animal Science, School of Science and Technology, Institute of Agriculture, Shinshu University, Nagano, Japan.
³ State Key Laboratory of Medical Molecular Biology, Department of Immunology, Research Center on Pediatric Development Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.
⁴ Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX, United States.

Comment

Vimal Selvaraj et al. Front Endocrinol (Lausanne). 2020.

. 2020 Jul 24:11:472.

doi: 10.3389/fendo.2020.00472. eCollection 2020.

¹ Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY, United States.
² Division of Animal Science, School of Science and Technology, Institute of Agriculture, Shinshu University, Nagano, Japan.
³ State Key Laboratory of Medical Molecular Biology, Department of Immunology, Research Center on Pediatric Development Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.
⁴ Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX, United States.

No abstract available

Keywords: Leydig cells; Sertoli cells; granulosa cells; mitochondria; ovary; steroidogenesis; testis; theca cells.

Comment on

Amhr2-Cre-Mediated Global Tspo Knockout.
Fan J, Campioli E, Sottas C, Zirkin B, Papadopoulos V. Fan J, et al. J Endocr Soc. 2020 Jan 12;4(2):bvaa001. doi: 10.1210/jendso/bvaa001. eCollection 2020 Feb 1. J Endocr Soc. 2020. PMID: 32099945 Free PMC article.

1. Fan J, Campioli E, Sottas C, Zirkin B, Papadopoulos V. Amhr2-cre–mediated global Tspo knockout. J Endocr Soc. (2020) 4:bvaa001. 10.1210/JENDSO/BVAA001 - DOI - PMC - PubMed
1. Selvaraj V, Tu LN, Stocco DM. Crucial role reported for TSPO in viability and steroidogenesis is a misconception. commentary: conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation. Front Endocrinol. (2016) 7:91. 10.3389/fendo.2016.00091 - DOI - PMC - PubMed
1. Morohaku K, Pelton SH, Daugherty DJ, Butler WR, Deng W, Selvaraj V. Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis. Endocrinology. (2014) 155:89–97. 10.1210/en.2013-1556 - DOI - PMC - PubMed
1. Jamin SP, Arango NA, Mishina Y, Hanks MC, Behringer RR. Requirement of Bmpr1a for Müllerian duct regression during male sexual development. Nat Genet. (2002) 32:408–10. 10.1038/ng1003 - DOI - PubMed
1. Migone FF, Hung P-H, Cowan RG, Selvaraj V, Suarez SS, Quirk SM. Overactivation of hedgehog signaling in the developing Müllerian duct interferes with duct regression in males and causes subfertility. Reproduction. (2017) 153:481–92. 10.1530/REP-16-0562 - DOI - PMC - PubMed