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Review
. 2020 Jul 21:8:509.
doi: 10.3389/fchem.2020.00509. eCollection 2020.

Alzheimer's Therapeutic Strategy: Photoactive Platforms for Suppressing the Aggregation of Amyloid β Protein

Chenglong Li  1 , Jie Wang  1 , Lei Liu  1
Affiliations
Review

Alzheimer's Therapeutic Strategy: Photoactive Platforms for Suppressing the Aggregation of Amyloid β Protein

Chenglong Li et al. Front Chem. .

Abstract

Neurodegenerative diseases such as Alzheimer's disease (AD) have become a public health problem. Progressive cerebral accumulation of amyloid protein (Aβ) was widely considered as the cause of AD. One promising strategy for AD preclinical study is to degrade and clear the deposited amyloid aggregates with β-sheet-rich secondary structure in the brain. Based on the requirement, photo-active materials with the specific excitation and the standardization of the photosensitizer preparation and application in clinics, have attracted increased attention in the study and treatment of neurodegenerative disease as a novel method termed as photodynamic therapy (PDT). This review will focus on the new photosensitizing materials and discuss the trend of PDT techniques for the possible application in the treatment strategy of amyloid-related diseases.

Keywords: amyloid protein; neurodegenerative disease; phostosensitive agent; photocatalyst; photodynamic therapy.

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Figures

Figure 1
Figure 1
An illustration of dissociation of Aβ42 aggregates by photo-excited MB. Reproduced with permission (Lee et al., 2017). Copyright 2017, Nature Publishing Group.
See this image and copyright information in PMC

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