Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jul;8(13):825.
doi: 10.21037/atm-20-2045a.

Effects of intravenous and inhalation anesthesia on blood glucose and complications in patients with type 2 diabetes mellitus: study protocol for a randomized controlled trial

Xing-Hui Xiong  1 , Chan Chen  1 , Hai Chen  1 , Rui Gao  1 , Qian-Yao Deng  1 , Xing-Wei Cai  1 , Peng Liang  1 , Tao Zhu  1
Affiliations

Effects of intravenous and inhalation anesthesia on blood glucose and complications in patients with type 2 diabetes mellitus: study protocol for a randomized controlled trial

Xing-Hui Xiong et al. Ann Transl Med. 2020 Jul.

Abstract

Background: Diabetes mellitus (DM) is a metabolic disorder syndrome caused by relative or absolute lack of insulin and varying degrees of insulin resistance. The type and regimen of anesthesia may affect perioperative hyperglycemia following major surgical stress. The effect of perioperative anesthetics on the blood glucose level of diabetic patients will play an essential role in the postoperative recovery of patients. However, there is no rigorously-designed randomized controlled trial to compare the effects of total intravenous anesthesia (TIVA) and total inhalation anesthesia (TIHA) on blood glucose and complications in type 2 diabetes. Hence, we design this clinical trial to compare the effects of TIVA and TIHA of hyperglycemia and clinical outcomes in type 2 diabetes undergoing surgery.

Methods: This is a randomized, double-blind, parallel controlled trial. One hundred twelve patients with type 2 DM who meet the qualification criteria will be randomly divided into two groups: TIVA group and TIHA group. The levels of serum insulin and cortisol will be measured before and after the operation, and the levels of blood glucose at different setting time will be monitored. All patients will be followed up by blinded evaluators at baseline and 1, 3, 7, and 30 days after the intervention. The follow-up included postoperative complications [such as myocardial infarction (MI), stroke, renal failure, anastomotic fistula, stress ulcer, incision infection, lung infection] and adverse events.

Discussion: The routinely used clinical anesthesia schemes are TIVA, TIHA and intravenous-inhalation combined anesthesia. We expect that the results of this trial will provide high-quality clinical evidence for the choice of anesthesia options for patients with type 2 DM.

Trial registration: Chinese Clinical Trial Registry: ChiCTR2000029247, registration date: 20 January 2020.

Keywords: Diabetes mellitus (DM); blood glucose; inhalation anesthesia; intravenous anesthesia; randomized double-blind controlled trial.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/atm-20-2045a). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Flow diagram of participants
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Wang L, Gao P, Zhang M, et al. Prevalence and Ethnic Pattern of Diabetes and Prediabetes in China in 2013. JAMA 2017;317:2515-23. 10.1001/jama.2017.7596 - DOI - PMC - PubMed
    1. Emerging Risk Factors Collaboration , Di Angelantonio E, Kaptoge S, et al. Association of Cardiometabolic Multimorbidity With Mortality. JAMA 2015;314:52-60. 10.1001/jama.2015.7008 - DOI - PMC - PubMed
    1. Kotagal M, Symons RG, Hirsch IB, et al. Perioperative hyperglycemia and risk of adverse events among patients with and without diabetes. Ann Surg 2015;261:97-103. 10.1097/SLA.0000000000000688 - DOI - PMC - PubMed
    1. Yeh CC, Liao CC, Chang YC, et al. Adverse outcomes after noncardiac surgery in patients with diabetes: a nationwide population-based retrospective cohort study. Diabetes care 2013;36:3216-21. 10.2337/dc13-0770 - DOI - PMC - PubMed
    1. Underwood P, Askari R, Hurwitz S, et al. Preoperative A1C and clinical outcomes in patients with diabetes undergoing major noncardiac surgical procedures. Diabetes care 2014;37:611-6. 10.2337/dc13-1929 - DOI - PubMed