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Review
. 2019 Dec 16;2(1):vdz035.
doi: 10.1093/noajnl/vdz035. eCollection 2020 Jan-Dec.

Laser interstitial thermal therapy

Katherine G Holste  1 , Daniel A Orringer  1
Affiliations
Review

Laser interstitial thermal therapy

Katherine G Holste et al. Neurooncol Adv. .

Abstract

Background: Laser interstitial thermal therapy (LITT) is becoming an increasingly popular technique for the treatment of brain lesions. More minimally invasive that open craniotomy for lesion resection, LITT may be more appropriate for lesions that are harder to access through an open approach, deeper lesions, and for patients who may not tolerate open surgery.

Methods: A search of the current primary literature on LITT for brain lesions on PubMed was performed. These studies were reviewed and updates on the radiological, pathological, and long-term outcomes after LITT for brain metastases, primary brain tumors, and radiation necrosis as well as common complications are included.

Results: Larger extent of ablation and LITT as frontline treatment were potential predictors of favorable progression-free and overall survival for primary brain tumors. In brain metastases, larger extent of ablation was more significantly associated with survival benefit, whereas tumor size was a possible predictor. The most common complications after LITT are transient and permanent weakness, cerebral edema, hemorrhage, seizures, and hyponatremia.

Conclusions: Although the current literature is limited by small sample sizes and primarily retrospective studies, LITT is a safe and effective treatment for brain lesions in the correct patient population.

Keywords: LITT; brain metastasis; brain tumor.

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Figures

Figure 1.
Figure 1.
The optical fiber, attached to the laser light system, is passed through a burr hole to the lesion of interest.
See this image and copyright information in PMC

References

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