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. 2020 Dec;105(6):773-778.
doi: 10.1111/ejh.13509. Epub 2020 Sep 20.

Characteristics of peripheral blood differential counts in hospitalized patients with COVID-19

Irene S Pakos  1 , Kevin Bryan Lo  1 , Grace Salacup  1 , Jerald Pelayo  1 , Ruchika Bhargav  1 , Eric Peterson  1 , Fahad Gul  1 , Robert DeJoy 3rd  1 , Jeri Albano  1 , Gabriel Patarroyo-Aponte  2   3 , Janani Rangaswami  1   3 , Zurab Azmaiparashvili  1
Affiliations

Characteristics of peripheral blood differential counts in hospitalized patients with COVID-19

Irene S Pakos et al. Eur J Haematol. 2020 Dec.

Abstract

Background: A lot remains unknown about the features and laboratory findings that may predict worse outcomes in patients with coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the difference in complete blood count parameters and differential counts in patients hospitalized with COVID-19 who survived compared to those who died.

Design: We performed a single-center retrospective study including 242 patients with confirmed COVID-19. We described the characteristics of the complete blood count parameters in these patients. Mann-Whitney U test was used to compare hematologic parameters of patients who died and those who survived; multivariate logistic regression was used to look for associations with mortality.

Results: Patients with COVID-19 who died had significantly lower median absolute monocyte count (AMC) (0.4 vs 0.5, P = .039) and median platelet count (169 vs 213, P = .009) compared to those who survived. Patients who died had a significantly higher neutrophil-to-lymphocyte ratio (6.4 vs 4.5, P = .001). The NLR was positively associated with death (OR = 1.038; 95% CI, 1.003-1.074, P = .031), while AMC was inversely associated with death (OR = 0.200; 95% CI, 0.052-0.761, P = .018).

Conclusion: Among patients with COVID-19, a lower AMC and higher NLR are associated with higher mortality.

Keywords: COVID-19; lymphopenia; monocytes; novel coronavirus.

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Conflict of interest statement

The authors declare no financial or commercial conflict of interest.

Figures

FIGURE 1
FIGURE 1
Study population [Colour figure can be viewed at wileyonlinelibrary.com]
See this image and copyright information in PMC

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