Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Aug 18;142(7):708-710.
doi: 10.1161/CIRCULATIONAHA.120.047911. Epub 2020 Jun 22.

Myocyte-Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2-Mediated Myocarditis

Nathan R Tucker #  1 , Mark Chaffin #  1 , Kenneth C Bedi Jr  2 , Irinna Papangeli  3 , Amer-Denis Akkad  3 , Alessandro Arduini  1 , Sikander Hayat  3 , Gökcen Eraslan  4 , Christoph Muus  5 , Roby P Bhattacharyya  4 , Christian M Stegmann  3 ; Human Cell Atlas Lung Biological Network; Kenneth B Margulies  2 , Patrick T Ellinor  1 ; Human Cell Atlas Lung Biological Network Consortium Members
Collaborators, Affiliations

Myocyte-Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2-Mediated Myocarditis

Nathan R Tucker et al. Circulation. .

Abstract

Supplemental Digital Content is available in the text.

Keywords: COVID-19; cardiovascular diseases; heart; myocarditis; severe acute respiratory syndrome coronavirus 2.

PubMed Disclaimer

Conflict of interest statement

Drs Papangeli, Akkad, Hayat, and Stegmann are employees of Bayer US LLC (a subsidiary of Bayer AG) and may own stock in Bayer AG. Dr Ellinor is supported by a grant from Bayer AG to the Broad Institute focused on the genetics and therapeutics of cardiovascular diseases. Dr Ellinor has also served on advisory boards or consulted for Bayer AG, Quest Diagnostics, MyoKardia, and Novartis. Dr Margulies has research grant funding from Sanofi-Aventis and has also served on advisory boards for MyoKardia and Pfizer. The other authors report no conflicts.

Figures

Figure.
Figure.
Assessment of ACE2 expression in the human myocardium. A, Dot plot representing the relative expression of ACE2, CTSL, and TMPRSS2 in the left ventricle. Size and hue of the dot indicates the percent of nuclei expressing and the mean of the log-transformed, normalized counts for all nuclei in each cell type. B, Expression of ACE2 by bulk RNA-Seq from nonfailing, dilated cardiomyopathy (DCM), and hypertrophic cardiomyopathy (HCM) ventricles. C, Single nucleus RNA-Seq from the same tissue samples as in B with mean expression of ACE2 in cell subtypes with appreciable expression. D, Effects of angiotensin-converting enzyme inhibitors (ACEis) on ACE2 expression across cell types in individuals with HCM. Boxes represent 25% to 75% and whiskers represent the minimum–maximum range, excluding outliers. ***P<0.001. CVD indicates cardiovascular disease; LEC, lymphatic endothelial cell; and VSMC, vascular smooth muscle cell.
See this image and copyright information in PMC

Update of

References

    1. Vaduganathan M, Vardeny O, Michel T, McMurray JJV, Pfeffer MA, Solomon SD. Renin–angiotensin–aldosterone system inhibitors in patients with COVID-19. N Engl J Med. 2020;382:1653–1659. doi:10.1056/nejmsr2005760 - PMC - PubMed
    1. Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F, Gong W, Liu X, Liang J, Zhao Q, et al. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA Cardiol 20205802–810doi: 10.1001/jamacardio.2020.0950 - PMC - PubMed
    1. Tucker NR, Chaffin M, Fleming SJ, Hall AW, Parsons VA, Bedi KC, Jr, Akkad A-D, Herndon CN, Arduini A, Papangeli I, et al. Transcriptional and cellular diversity of the human heart [published online May 14, 2020]. Circulation. doi: 10.1161/circulationaha.119.045401. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.045401. - DOI - PMC - PubMed
    1. Chen L, Li X, Chen M, Feng Y, Xiong C. The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2. Cardiovasc Res 20201161097–1100doi: 10.1093/cvr/cvaa078 - PMC - PubMed
    1. Nicin L, Abplanalp WT, Mellentin H, Kattih B, Tombor L, John D, Schmitto JD, Heineke J, Emrich F, Arsalan M, et al. Cell type-specific expression of the putative SARS-CoV-2 receptor ACE2 in human hearts. Eur Heart J 2020411804–1806doi: 10.1093/eurheartj/ehaa311 - PMC - PubMed

Publication types

MeSH terms