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Meta-Analysis
. 2020 Aug 14;20(1):266.
doi: 10.1186/s12876-020-01406-9.

Association of Helicobacter pylori vacA genotypes and peptic ulcer in Iranian population: a systematic review and meta-analysis

Masoud Keikha  1   2   3 , Mohammad Ali-Hassanzadeh  4 , Mohsen Karbalaei  5
Affiliations
Meta-Analysis

Association of Helicobacter pylori vacA genotypes and peptic ulcer in Iranian population: a systematic review and meta-analysis

Masoud Keikha et al. BMC Gastroenterol. .

Abstract

Background: Helicobacter pylori is accounted as the most etiologic agent for digestive disorders, in particular, the most important of them i.e. peptic ulcer and gastric cancer. In the recent years, association of vacA genotypes and gastrointestinal disorders has attracted a lot of attention. In present study, we assessed the correlation between vacA genotypes (s1, s2, m1, m2, s1m1, s1m2, s2m1 and s2m2) and development to peptic ulcer in Iranian population.

Methods: In our study, first, 24 original articles containing of information of 3328 patients were evaluated. Statistical analysis was done by Comprehensive Meta-Analysis version 2.0 software (Biostat, Englewood, NJ, USA). In this regards, we used from fixed-effects model for analysis of data with low heterogeneity, while for analysis of data with high heterogeneity (I2 statistic index > 25%, Cochrane Q statistic p value < 0.05), random-effects model was used.

Results: Abundance of each of s1, s2, m1, m2, s1m1, s1m2, s2m1, and s2m2 was estimated 36.24, 28.32, 42.90 29.86, 27.88, 32.34, 15.70, and 25.94%, respectively. According to the results, the m1, s1, and s1m2 genotypes were among the most prevalent genotypes among the Iranian patients, whereas, s2m1 genotype had the lowest frequency.

Conclusions: Overall, 24 articles (total participants = 3328) were included in this comprehensive analysis. H. pylori infection rate were 90.26% in these cases, so that 33.65% of whom had peptic ulcer. Moreover, the abundance of each vacA genotypes including s1, s2, m1, m2, s1m1, s1m2, s2m1, and s2m2 was estimated as 36.24, 28.32, 42.90 29.86, 27.88, 32.34, 15.70, and 25.94% respectively. We demonstrated that there is a significant relationship between infection of stomach with m1, s1m1, and s2m1 genotypes and development to peptic ulcer disease.

Keywords: Helicobacter pylori; Iran; Peptic ulcer disease; vacA genotypes.

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Conflict of interest statement

There is no any conflict of interest among the all authors.

Figures

Fig. 1
Fig. 1
Flowchart of included and excluded articles
Fig. 2
Fig. 2
Forrest plot of the vacA genotype m1.The association between vacA genotype m1 and development to peptic ulcer in Iranian populations
Fig. 3
Fig. 3
Forrest plot of the vacA genotype s1m1.The association between vacA genotype s1m1 and development to peptic ulcer in Iranian populations
Fig. 4
Fig. 4
Forrest plot of the vacA genotype s2m1. The association between vacA genotype s2m1 and development to peptic ulcer in Iranian populations
Fig. 5
Fig. 5
Forrest plot of the association of coexistence vacA/cagA with development of disease to peptic ulcer in Iranian populations
See this image and copyright information in PMC

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