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. 2020 Nov:88:106879.
doi: 10.1016/j.intimp.2020.106879. Epub 2020 Aug 8.

Oxygen-ozone (O2-O3) immunoceutical therapy for patients with COVID-19. Preliminary evidence reported

Marianno Franzini  1 , Luigi Valdenassi  1 , Giovanni Ricevuti  2 , Salvatore Chirumbolo  3 , Markus Depfenhart  4 , Dario Bertossi  5 , Umberto Tirelli  6
Affiliations

Oxygen-ozone (O2-O3) immunoceutical therapy for patients with COVID-19. Preliminary evidence reported

Marianno Franzini et al. Int Immunopharmacol. 2020 Nov.

Abstract

Objective: This study evaluated the potential efficacy of a novel approach to treat COVID-19 patients, using an oxygen-ozone (O2-O3) mixture, via a process called Oxygen-Ozone- Immunoceutical Therapy. The methodology met the criteria of a novel, promising approach to treat successfully elderly COVID-19 patients, particularly when hospitalized in intensive care units (ICUs) Experimental design: We investigated the therapeutic effect of 4 cycles of O2-O3 in 50 hospitalized COVID-19 subjects suffering from acute respiratory disease syndrome (ARDS), aged more than 60 years, all males and undergoing non invasive mechanical ventilation in ICUs.

Results: Following O2-O3 treatment a significant improvement in inflammation and oxygenation indexes occurred rapidly and within the first 9 days after the treatment, despite the expected 14-20 days. A significant reduction of inflammatory and thromboembolic markers (CRP, IL-6, D-dimer) was observed. Furthermore, amelioration in the major respiratory indexes, such as respiratory and gas exchange markers (SatO2%, PaO2/FiO2 ratio), was reported.

Conclusion: Our results show that O2-O3 treatment would be a promising therapy for COVID-19 patients. It leads patients to a fast recovery from ARDS via the improvement of major respiratory indexes and blood gas parameters, following a relatively short time of dispensed forced ventilation (about one to two weeks). This study may encourage the scientific community to further investigate and evaluate the proposed method for the treatment of COVID-19 patients.

Keywords: COVID-19; D-dimer; IL-6; Immunoceutical; Oxygen; Ozone therapy; Pneumonia.

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Figures

Fig. 1
Fig. 1
(A) Box plots of the delta percentage (delta%) of major blood gas analysis and respiratory gaseous indexes before and after the last O2-O3 treatment [(last – before)/before]*100; (B) Delta % of D-dimer (ng/ml) before and after the last O2-O3treatment [(last – before)/before]*100 t; (C) Delta % of IL-6 (IU/L) before and after the last O2-O3 treatment [(last – before)/before]*100; (D) Time course of Sat O2 % in respect to the different treatments points. In the small panel the delta % of cumulated data from before and from the last performed treatment (8.6 ± 1.4 days of treatment, Wilcoxon p = 0.000234). Statistics SPSS v 24.0. Plots with Sigma Plot v 13.0.
See this image and copyright information in PMC

References

    1. Li T., Lu H., Zhang W. Clinical observation and management of COVID-19 patients. Emerg. Microbes Infect. 2020;9(1):687–690. - PMC - PubMed
    1. Lauer S.A., Grantz K.H., Bi Q., Jones F.K., Zheng Q., Meredith H.R., Azman A.S., Reich N.G., Lessler J. The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application. Ann. Intern. Med. 2020;172(9):577–582. - PMC - PubMed
    1. Wu D., Wu T., Liu Q., Yang Z. The SARS-CoV-2 outbreak: What we know [published online ahead of print, 2020 Mar 12] Int. J. Infect. Dis. 2020;94:44–48. - PMC - PubMed
    1. Liu J., Zheng X., Tong Q., Li W., Wang B., Sutter K., Trilling M., Lu M., Dittmer U., Yang D. Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS‐CoV, MERS‐CoV, and 2019‐nCoV. J Med Virol. 2020;92(5):491–494. - PMC - PubMed
    1. Ruan Q., Yang K., Wang W., Jiang L., Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 2020;46(5):846–848. - PMC - PubMed

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