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. 2020 Sep;146(3):e20200737.
doi: 10.1542/peds.2020-0737. Epub 2020 Aug 13.

Neonatal Adiposity and Childhood Obesity

Brianna F Moore  1   2 , Kylie K Harrall  2 , Katherine A Sauder  2   3 , Deborah H Glueck  3 , Dana Dabelea  4   3   5
Affiliations

Neonatal Adiposity and Childhood Obesity

Brianna F Moore et al. Pediatrics. 2020 Sep.

Abstract

Objectives: To explore the longitudinal association of neonatal adiposity (fat mass percentage) with BMI trajectories and childhood overweight and obesity from ages 2 to 6 years.

Methods: We studied 979 children from the Healthy Start cohort. Air displacement plethysmography was used to estimate fat mass percentage. Child weight and recumbent length or standing height were abstracted from medical records. Overweight and obesity were defined as BMI levels ≥85th percentile for age and sex. Mixed-effects models were used to examine the association between neonatal fat mass percentage and BMI trajectories from age 2 to 6 years. We tested for effect modification by sex, race and/or ethnicity, and breastfeeding duration. We estimated the proportion of children classified as overweight or obese at specific levels of neonatal fat mass percentage (mean ± SD).

Results: The mean neonatal adiposity level was 9.1% ± 4.0%. Child BMI levels differed by neonatal adiposity. Each SD increase in neonatal adiposity resulted in a 0.12 higher overall BMI level between ages 2 to 6 years (95% confidence interval: 0.03 to 0.20; P < .01), and this association was not modified by offspring sex, race and/or ethnicity, or breastfeeding duration. Increasing neonatal adiposity was associated with an increasing proportion of childhood overweight and obesity by age 5 years (P = .02).

Conclusions: We provide novel evidence that higher neonatal adiposity is significantly associated with higher overall BMI levels and an increased likelihood of overweight or obesity from ages 2 to 6 years. Because various prenatal exposures may specifically influence offspring fat accretion, neonatal adiposity may be a useful surrogate end point for prenatal interventions aimed at reducing future childhood overweight and obesity.

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Conflict of interest statement

POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.

Figures

FIGURE 1
FIGURE 1
Predicted BMI levels according to neonatal adiposity.
See this image and copyright information in PMC

Comment in

References

    1. Ogden CL, Carroll MD, Lawman HG, et al. . Trends in obesity prevalence among children and adolescents in the United States, 1988-1994 through 2013-2014. JAMA. 2016;315(21):2292–2299 - PMC - PubMed
    1. Skinner AC, Ravanbakht SN, Skelton JA, Perrin EM, Armstrong SC. Prevalence of obesity and severe obesity in US children, 1999-2016. [published correction appears in Pediatrics. 2018;142(30):e20181916]. Pediatrics. 2018;141(3):e20173459. - PMC - PubMed
    1. Al-Hamad D, Raman V. Metabolic syndrome in children and adolescents. Transl Pediatr. 2017;6(4):397–407 - PMC - PubMed
    1. Oken E. Maternal and child obesity: the causal link. Obstet Gynecol Clin North Am. 2009;36(2):361–377, ix–x - PubMed
    1. Mustila T, Raitanen J, Keskinen P, Luoto R. A pragmatic controlled trial to prevent childhood obesity within a risk group at maternity and child health-care clinics: results up to six years of age (the VACOPP study). BMC Pediatr. 2018;18(1):89. - PMC - PubMed

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