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Case Reports
. 2020 Oct;45(10):838-839.
doi: 10.1097/RLU.0000000000003214.

18F-Florbetapir PET in Primary Cerebral Amyloidoma

Frederik Soffers  1 , Sarah Ceyssens  1 , Wendi Buffet  2 , Didier de Surgeloose  3 , Roeland Crols  4
Affiliations
Case Reports

18F-Florbetapir PET in Primary Cerebral Amyloidoma

Frederik Soffers et al. Clin Nucl Med. 2020 Oct.

Abstract

Amyloid deposition can lead to Alzheimer disease and cerebral amyloid angiopathy. Rarely, it presents as a solitary focal deposition, primary cerebral amyloidoma, which can be misinterpreted as a neoplasm because of the "tumor-like" appearances. We present the case of a 54-year-old woman where MRI revealed a T2-hyperintense mass periventricular in the white matter with moderate contrast enhancement. Pathological investigation revealed AL (lambda) amyloidoma. F-florbetapir PET/CT was used to support the diagnosis and in follow-up. This case highlights that F-florbetapir PET/CT might play a role in the diagnostic workup of patients suggestive of cerebral amyloidoma, especially in cases where biopsy is not feasible.

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