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Review
. 2020 Sep 9;28(3):364-370.
doi: 10.1016/j.chom.2020.08.002. Epub 2020 Aug 10.

Approaches and Challenges in SARS-CoV-2 Vaccine Development

Gabriel Dagotto  1 , Jingyou Yu  1 , Dan H Barouch  2
Affiliations
Review

Approaches and Challenges in SARS-CoV-2 Vaccine Development

Gabriel Dagotto et al. Cell Host Microbe. .

Abstract

The explosive spread of SARS-CoV-2 suggests that a vaccine will be required to end this global pandemic. Progress in SARS-CoV-2 vaccine development to date has been faster than for any other pathogen in history. Multiple SARS-CoV-2 vaccine candidates have been evaluated in preclinical models and are currently in clinical trials. In this Perspective, we discuss three topics that are critical for SARS-CoV-2 vaccine development: antigen selection and engineering, preclinical challenge studies in non-human primate models, and immune correlates of protection.

Keywords: COVID-19; SARS-CoV-2; vaccine.

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Conflict of interest statement

Declaration of Interests Correspondence and requests for materials should be addressed to D.H.B. (dbarouch@bidmc.harvard.edu). D.H.B. is a co-inventor on provisional vaccine patents (62/969,008; 62/994,630) that have been licensed.

Figures

Figure 1
Figure 1
SARS-CoV-2 Spike Graphical representation of the SARS-CoV-2 S protein sequence and crystal structure of SARS-CoV-2 S protein ectodomain (PDB: 6VSB) (Wrapp et al., 2020) created by using PyMol software. The transmembrane domain and cytoplasmic tail were not crystallized. TM, transmembrane domain; CT, cytoplasmic tail.
See this image and copyright information in PMC

References

    1. Akerström S., Tan Y.J., Mirazimi A. Amino acids 15-28 in the ectodomain of SARS coronavirus 3a protein induces neutralizing antibodies. FEBS Lett. 2006;580:3799–3803. - PMC - PubMed
    1. Altmann D.M., Boyton R.J. SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection. Sci. Immunol. 2020;5:eabd6160. - PubMed
    1. Arons M.M., Hatfield K.M., Reddy S.C., Kimball A., James A., Jacobs J.R., Taylor J., Spicer K., Bardossy A.C., Oakley L.P., et al. Public Health–Seattle and King County and CDC COVID-19 Investigation Team Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility. N. Engl. J. Med. 2020;382:2081–2090. - PMC - PubMed
    1. Barrow G.I., Higgins P.G., al-Nakib W., Smith A.P., Wenham R.B.M., Tyrrell D.A.J. The effect of intranasal nedocromil sodium on viral upper respiratory tract infections in human volunteers. Clin. Exp. Allergy. 1990;20:45–51. - PMC - PubMed
    1. Baum A., Fulton B.O., Wloga E., Copin R., Pascal K.E., Russo V., Giordano S., Lanza K., Negron N., Ni M., et al. Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies. Science. 2020:eabd0831. - PMC - PubMed

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