Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jan;32(1):153-5.
doi: 10.1128/AAC.32.1.153.

Increase in permeability of Escherichia coli outer membrane by local anesthetics and penetration of antibiotics

B Labedan  1
Affiliations

Increase in permeability of Escherichia coli outer membrane by local anesthetics and penetration of antibiotics

B Labedan. Antimicrob Agents Chemother. 1988 Jan.

Abstract

The MICs of several antibiotics (both hydrophobic and hydrophilic) which penetrate very poorly into intact Escherichia coli cells were found to be 2- to 10-fold decreased in the presence of low doses of various local anesthetics (procaine, dibucaine, tetracaine, chlorpromazine, and quinine). The concentrations of anesthetics necessary for this effect have no adverse effect on cell growth and are markedly lower than those concentrations used clinically.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Biochem Biophys Res Commun. 1965 Nov 22;21(4):290-6 - PubMed
    1. Pharmacol Rev. 1972 Dec;24(4):583-655 - PubMed
    1. Ann N Y Acad Sci. 1974 May 10;235(0):109-29 - PubMed
    1. Proc Natl Acad Sci U S A. 1976 Dec;73(12):4474-8 - PubMed
    1. Microbiol Rev. 1985 Mar;49(1):1-32 - PubMed

MeSH terms