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. 1988 Jan;32(1):92-5.
doi: 10.1128/AAC.32.1.92.

Pharmacokinetics and serum bactericidal activity of vancomycin alone and in combination with ceftazidime in healthy volunteers

M Boeckh  1 , H Lode, K Borner, G Höffken, J Wagner, P Koeppe
Affiliations

Pharmacokinetics and serum bactericidal activity of vancomycin alone and in combination with ceftazidime in healthy volunteers

M Boeckh et al. Antimicrob Agents Chemother. 1988 Jan.

Abstract

The pharmacokinetics and serum bactericidal activity of vancomycin alone and in combination with ceftazidime were investigated in 10 healthy volunteers. The pharmacokinetic parameters showed no significant differences (P less than 0.05) between single and combined administration. No antagonistic effects were observed in serum bactericidal activity with the combination against 20 gram-positive and 20 gram-negative locally isolated bacteria. A titer of greater than or equal to 1:8 was generated by the combination against all test strains except enterococci. Seven of ten volunteers developed a typical "red man's syndrome" during the administration of 1.0 g of vancomycin.

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References

    1. J Infect Dis. 1974 Feb;129(2):187-93 - PubMed
    1. Antimicrob Agents Chemother. 1987 Mar;31(3):393-7 - PubMed
    1. J Infect Dis. 1977 Aug;136(2):196-204 - PubMed
    1. J Clin Pharmacol. 1980 Apr;20(4 Pt 1):197-201 - PubMed
    1. Ther Drug Monit. 1979;1(1):75-83 - PubMed

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