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. 2021 Mar;20(3):922-928.
doi: 10.1111/jocd.13679. Epub 2020 Sep 21.

Consensus report on the use of PN-HPT™ (polynucleotides highly purified technology) in aesthetic medicine

Maurizio Cavallini  1 , Emanuele Bartoletti  2 , Laura Maioli  3 , Alberto Massirone  4 , Isabella Pia Palmieri  5 , Marco Papagni  6 , Maurizio Priori  7 , Gloria Trocchi  8 ; As Members of The Polynucleotides HPT™ Priming Board, Collegio Italiano delle Società Scientifiche di Medicina Estetica (Italian College of the Aesthetic Medicine Scientific Societies) - SIME, AGORÀ, SIES
Affiliations

Consensus report on the use of PN-HPT™ (polynucleotides highly purified technology) in aesthetic medicine

Maurizio Cavallini et al. J Cosmet Dermatol. 2021 Mar.

Abstract

Background: Injective procedures using polynucleotides-based products to promote dermal rejuvenation and revitalization are steadily evolving, yet no structured protocols are available that discuss and provide guidance in aesthetic treatments with highly purified polynucleotides. The goal of this document was to provide consensus-based recommendations for the safe and effective use of Polynucleotides Highly Purified Technology™ (PN-HPT™) devices for skin rejuvenation.

Patients/methods: A team of eight experts with extensive experience in treatments for skin rejuvenation and revitalization integrated the best available evidence and clinical judgment and devised a series of practical guidance to support dermatologists, plastic surgeons, and aesthetic physician in the use of PN-HPT™ products, alone and in combination, in aesthetic medicine.

Results: For most items, the expert group achieved a majority consensus. "Recommendations" (consensus >80%) were reached for the face, periocular area, décolleté and neck, hands, scalp, and stretch marks. Recommendations include details of techniques, information on dosage, volumes to be injected, and the ideal number of required treatment sessions, as well as time intervals between them for different areas of face and body. A lower agreement level of 60% was reached on but one item related to the initial treatment cycle for the face, leading to a "Consensus statement" for that area instead of a full "Recommendation."

Conclusion: The expert consensus illustrates the value of natural-origin, highly purified polynucleotides (PN-HPT™) as biostimulatory booster strategy for skin priming and revitalization of face and body and provides a detailed guide for the use.

Keywords: PN-HPT™; polynucleotides; polynucleotides highly purified technology™; skin priming; skin rejuvenation.

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Conflict of interest statement

All the members of Scientific Board variably received grants from several aesthetic medicine companies as consultants for research and development and/or continuing medical education activities and/or for participating as investigators to national and international clinical studies in aesthetic medicine and surgery. Past sponsors of the members of the Board included Mastelli Srl., Sanremo, Italy, holder of the PN‐HPT™ patents and producer of PN‐HPT™‐based medical devices. The development of both the digital survey and the consensus report about PN‐HPT™ and their role in aesthetic medicine was spurred by the acute need for expert guidelines in the fast‐changing aesthetic medicine field. Competing interests were carefully avoided by all members of the Board. Mastelli Srl. supported only the secretarial and logistic expenses of the Scientific Board and will financially support the publication costs of the Consensus after acceptance of the manuscript.

References

    1. Park KY, Seok J, Rho NK, Kim BJ, Kim MN. Long‐chain polynucleotide filler for skin rejuvenation: efficacy and complications in five patients. Dermatol Ther. 2016;29:37‐40. - PubMed
    1. Gianfaldoni R, Gianfaldoni S, Nannipieri A, Lotti T. A polynucleotide‐based product to treat female hormonal hair loss. Prime. 2014;30‐36.
    1. D’Aloiso MC. Tightening upper arms skin laxity with intradermal polynucleotides gel biorevitalization. LME‐La Medicina Estetica. 2016;40:102‐107.
    1. Cavallini M, Papagni M. Long‐chain polynucleotides gel and skin biorevitalization. J Plast Dermatol. 2007;3:3.
    1. Sundaram H, Mehta RC, Norine JA, et al. Topically applied physiologically balanced growth factors: a new paradigm of skin rejuvenation. J Drugs Dermatol. 2009;8(5 suppl):4‐13. - PubMed

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