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. 1988 Feb;31(2):248-57.
doi: 10.1002/art.1780310213.

Evidence that a humoral immune response to autologous cartilage proteoglycan can participate in the induction of cartilage pathology

T F Kresina  1 , J U Yoo, V M Goldberg
Affiliations

Evidence that a humoral immune response to autologous cartilage proteoglycan can participate in the induction of cartilage pathology

T F Kresina et al. Arthritis Rheum. 1988 Feb.

Abstract

We examined antiproteoglycan antibodies as an autoimmune response for induction of synovitis. This hypothesis was studied by monitoring humoral antiproteoglycan antibody following IgG induction of experimental immune synovitis, localization in the articular cartilage of an autologous immune response, and loss of proteoglycan from cartilage following intravenous administration of antiproteoglycan monoclonal antibodies. The data support the hypothesis that autoimmunity to cartilage macromolecules may play a role in the etiopathogenesis of arthritis.

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