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. 2020 Aug 15;20(1):302.
doi: 10.1186/s12883-020-01876-0.

Association between white matter impairment and cognitive dysfunction in patients with ischemic Moyamoya disease

Ziqi Liu  1 , Shihao He  1 , Zongsheng Xu  2 , Ran Duan  2 , Li Yuan  3 , Chu Xiao  4 , Zhe Yi  4 , Rong Wang  5   6   7
Affiliations

Association between white matter impairment and cognitive dysfunction in patients with ischemic Moyamoya disease

Ziqi Liu et al. BMC Neurol. .

Abstract

Background: Ischemic Moyamoya disease is one of the important causes of stroke, which leads to severe impairment in cognitive functions. This cognitive impairment occurs prior to stroke. However, the cognitive functions that are impaired and the mechanisms of these impairments have not been determined.

Methods: We analyzed 12 patients with Moyamoya disease and 12 controls. All participants underwent cognitive tests and magnetic resonance imaging (MRI) scans. The diffusion tensor imaging (DTI) data was processed using Tract-Based Spatial Statistics (TBSS). Significantly different white matter areas were correlated with different cognitive functions.

Results: There were significant differences in intelligence and subtraction between the patients and controls (p < 0.05). The parameters of DTI such as fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) have different changes in anterior thalamic radiation, inferior fronto-occipital fasciculus (IFO), superior longitudinal fasciculus (SLF), uncinate fasciculus (UF), inferior longitudinal fasciculus, forceps minor, and other regions between the two groups.

Conclusion: Left UF and IFO may be the key brain regions affecting arithmetic function, while bilateral IFO has an effect on intelligence. RD and AD may be better indicators for early prediction of chronic white matter damage than FA, while MD tends to have a comprehensive indirect change. There is cognitive impairment in ischemic MMD, which is closely related to white matter impairment.

Trial registration: Clinical Trial Registration, Unique identifier: ChiCTR1900023610 . Registered 4 June 2019 - Prospective study registered.

Keywords: Cognitive dysfunction; Diffusion tensor imaging; Ischemic cerebrovascular disease; Moyamoya disease; Tract-based spatial statistics.

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Conflict of interest statement

There are no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
Differences in FA, MD, RD, and AD values in different regions of the white matter between the patient group and control group after 5000 permutations and TFCE corrected p<0.05 (MD, AD, RD) or TFCE uncorrected p<0.05 (FA)
Fig. 2
Fig. 2
Correlation of cognition and WM regions in MMD group
Fig. 3
Fig. 3
Correlation of cognition and WM regions in control group
See this image and copyright information in PMC

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