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Comparative Study
. 2020 Aug 14;20(1):373.
doi: 10.1186/s12872-020-01658-z.

Implications of AB0 blood group in hypertensive patients with covid-19

Celestino Sardu  1   2 , Raffaele Marfella  3 , Paolo Maggi  4 , Vincenzo Messina  4 , Paolo Cirillo  4 , Vinicio Codella  4 , Jessica Gambardella  5   6 , Antonio Sardu  7 , Gianluca Gatta  3 , Gaetano Santulli  5   6 , Giuseppe Paolisso  3
Affiliations
Comparative Study

Implications of AB0 blood group in hypertensive patients with covid-19

Celestino Sardu et al. BMC Cardiovasc Disord. .

Abstract

Background: Hypertension is the most frequent co-morbidity in patients with covid-19 infection, and we might speculate that a specific blood group could play a key role in the clinical outcome of hypertensive patients with covid-19.

Methods: In this prospective study, we compared 0 vs. non-0 blood group in hypertensive patients with covid-19 infection. In these patients, we evaluated inflammatory and thrombotic status, cardiac injury, and death events.

Results: Patients in non-0 (n = 92) vs. 0 blood group (n = 72) had significantly different values of activated pro-thrombin time, D-dimer, and thrombotic indexes as Von Willebrand factor and Factor VIII (p < 0.05). Furthermore, patients in non-0 vs. 0 blood group had higher rate of cardiac injury (10 (13.9%) vs. 27 (29.3%)) and death, (6 (8.3%) vs. 18 (19.6%)), (p < 0.05). At the multivariate analysis, Interleukin-6 (1.118, CI 95% 1.067-1.171) and non-0 blood group (2.574, CI 95% 1.207-5.490) were independent predictors of cardiac injury in hypertensive patients with covid-19. D-dimer (1.082, CI 95% 1.027-1.140), Interleukin-6 (1.216, CI 95% 1.082-1.367) and non-0 blood group (3.706, CI 95% 1.223-11.235) were independent predictors of deaths events in hypertensive patients with covid-19.

Conclusions: Taken together, our data indicate that non-0 covid-19 hypertensive patients have significantly higher values of pro-thrombotic indexes, as well as higher rate of cardiac injury and deaths compared to 0 patients. Moreover, AB0 blood type influences worse prognosis in hypertensive patients with covid-19 infection.

Keywords: Coagulopathy; Covid-19; Hypertension.

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Conflict of interest statement

none to declare.

Figures

Fig. 1
Fig. 1
In this figure the actuarial probabilities calculated according to Kaplan-Meier survivor curve free from Cardiac Injury (upper part, χ 2 = 5.045, p = 0.025), and for Deaths (lower part, χ 2 = 3.880, p = 0.025). Green color: group 0; blu color: group non-0; *:p < 0.05
See this image and copyright information in PMC

Update of

References

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