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. 2020 Aug 15;18(1):208.
doi: 10.1186/s12957-020-01994-6.

A single-center experience with pancreatic cystic neuroendocrine tumors

Ange Khalil  1 , Jacques Ewald  2 , Ugo Marchese  2 , Aurélie Autret  3 , Jonathan Garnier  2 , Patricia Niccoli  4 , Gilles Piana  5 , Flora Poizat  6 , Marc Giovannini  7 , Jean-Robert Delpero  2 , Olivier Turrini  8
Affiliations

A single-center experience with pancreatic cystic neuroendocrine tumors

Ange Khalil et al. World J Surg Oncol. .

Abstract

Background: Pancreatic neuroendocrine tumors (PNET) are rare, with a significant malignant potential. This study aimed to determine outcomes of patients with resected PNETs according to the cystic component and confirm the accuracy of preoperative staging.

Methods: From 1997 to 2016, 106 patients underwent resection of PNETs, including 73 purely solid (S-PNETs, 69%), 21 mixed (M-PNETs, 20%), and 12 purely cystic lesions (C-PNETs, 11%). To ensure consistent comparisons of overall (OS) and disease-free (DFS) survival outcomes between the 3 groups, the patients were matched according to the World Health Organization (WHO) grade and tumor height.

Results: Overall, the rate of correlation between the preoperative and pathological diagnoses was low in the C-PNET group (33%, P = 0.03). None of the 24 patients (23%) with metastatic disease at the time of surgery were in the C-PNET group. Furthermore, significantly more parenchyma-sparing resections (P = 0.039) and fewer enlarged resections (P = 0.019) were achieved in the C-PNET group. C-PNET group had a significantly lower node invasion rate than the S-PNET and M-PNET groups (8% vs. 41% and 24%, P = 0.004). Although median OS was comparable in all 3 groups before (P = 0.3) and after (P = 0.18) matching, higher median DFS was observed in the C-PNET group than in the other groups after matching (P = 0.038).

Conclusion: C-PNET was associated with a better prognosis than PNET with a solid component. The results support a wait-and-see policy in cases wherein a reliable preoperative diagnosis remains challenging.

Keywords: Cystic component; Pancreatic neuroendocrine tumor; Survival.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Overall survival after matching
Fig. 2
Fig. 2
Disease-free survival after matching
See this image and copyright information in PMC

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