Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Aug 17:148:e170.
doi: 10.1017/S0950268820001661.

Burden of respiratory syncytial virus hospitalisation among infants born at 32-35 weeks' gestational age in the Northern Hemisphere: pooled analysis of seven studies

M Lanari  1 , E J Anderson  2 , M Sheridan-Pereira  3 , X Carbonell-Estrany  4 , B Paes  5 , B S Rodgers-Gray  6 , J R Fullarton  6 , E Grubb  7 , M Blanken  8
Affiliations

Burden of respiratory syncytial virus hospitalisation among infants born at 32-35 weeks' gestational age in the Northern Hemisphere: pooled analysis of seven studies

M Lanari et al. Epidemiol Infect. .

Abstract

To provide comprehensive information on the epidemiology and burden of respiratory syncytial virus hospitalisation (RSVH) in preterm infants, a pooled analysis was undertaken of seven multicentre, prospective, observational studies from across the Northern Hemisphere (2000-2014). Data from all 320-356 weeks' gestational age (wGA) infants without comorbidity were analysed. RSVH occurred in 534/14 504 (3.7%) infants; equating to a rate of 5.65 per 100 patient-seasons, with the rate in individual wGA groups dependent upon exposure time (P = 0.032). Most RSVHs (60.1%) occurred in December-January. Median age at RSVH was 88 days (interquartile range (IQR): 54-159). Respiratory support was required by 82.0% of infants: oxygen in 70.4% (median 4 (IQR: 2-6) days); non-invasive ventilation in 19.3% (median 3 (IQR: 2-5) days); and mechanical ventilation in 10.2% (median 5 (IQR: 3-7) days). Intensive care unit admission was required by 17.9% of infants (median 6 days (IQR: 2-8) days). Median overall hospital length of stay (LOS) was 5 (IQR: 3-8) days. Hospital resource use was similar across wGA groups except for overall LOS, which was shortest in those born 35 wGA (median 3 vs. 4-6 days for 32-34 wGA; P < 0.001). Strategies to reduce the burden of RSVH in otherwise healthy 32-35 wGA infants are indicated.

Keywords: Epidemiology; Lower respiratory tract infection; Moderate-to-late preterm infants; RSV hospitalisation; Respiratory support; Respiratory syncytial virus.

PubMed Disclaimer

Conflict of interest statement

EJA, ML, XC-E, MB, MS-P, BP have received research funding and/or compensation as advisor/lecturer from AbbVie. EJA has received research funding from MedImmune, Regeneron, Pfizer, Merck, Novavax, GSK, Sanofi Pasteur, PaxVax and Micron. EJA has received compensation from Pfizer for consulting. BRG and JF, working for Strategen, have previously received payment from AbbVie for work on various projects. EG is an employee of AbbVie and owns stock.

Figures

Fig. 1.
Fig. 1.
Derivation of pooled dataset.
Fig. 2.
Fig. 2.
Distribution of RSVH incidence by month*
See this image and copyright information in PMC

References

    1. Bont L et al. (2016) Defining the epidemiology and burden of severe respiratory syncytial virus infection among infants and children in western countries. Infectious Diseases and Therapy 5, 271–298. - PMC - PubMed
    1. Shi T et al. (2017) Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study. Lancet (London, England) 390, 946–958. - PMC - PubMed
    1. Thwaites R et al. (2020) Clinical burden of severe respiratory syncytial virus infection during the first 2 years of life in children born between 2000 and 2011 in Scotland. European Journal of Pediatrics 179, 791–799. - PMC - PubMed
    1. Checchia PA et al. (2017) Defining the risk and associated morbidity and mortality of severe respiratory syncytial virus infection among infants with congenital heart disease. Infectious Diseases and Therapy 6, 37–56. - PMC - PubMed
    1. Paes B et al. (2016) Defining the risk and associated morbidity and mortality of severe respiratory syncytial virus infection among infants with chronic lung disease. Infectious Diseases and Therapy 5, 453–471. - PMC - PubMed

Publication types

MeSH terms

Substances