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Review
. 2020 Aug;99(6):151099.
doi: 10.1016/j.ejcb.2020.151099. Epub 2020 Jul 2.

SRSF3: Newly discovered functions and roles in human health and diseases

Dhanashree Anil More  1 , Arun Kumar  2
Affiliations
Review

SRSF3: Newly discovered functions and roles in human health and diseases

Dhanashree Anil More et al. Eur J Cell Biol. 2020 Aug.

Abstract

The serine/arginine rich proteins (SR proteins) are members of a family of RNA binding proteins involved in regulating various features of RNA metabolism, including pre-mRNA constitutive and alternative splicing. In humans, a total of 12 SR splicing factors (SRSFs) namely SRSF1-SRSF12 have been reported. SRSF3, the smallest member of the SR family and the focus of this review, regulates critical steps in mRNA metabolism and has been shown to have mRNA-independent functions as well. Recent studies on SRSF3 have uncovered its role in a wide array of complex biological processes. We have also reviewed the involvement of SRSF3 in disease conditions like cancer, ageing, neurological and cardiac disorders. Finally, we have discussed in detail the autoregulation of SRSF3 and its implications in cancer and commented on the potential of SRSF3 as a therapeutic target, especially in the context of cancer.

Keywords: Cancer; Disease; SR proteins; SRSF; SRSF3; Splicing factors.

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Conflict of interest statement

Declaration of Competing Interest Both authors declare that there are no conflicts of interests, no financial affiliation or involvement with any commercial organization with direct financial interest in the subject or materials discussed in this manuscript.

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