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Comment
. 2020 Oct;36(10):802-804.
doi: 10.1016/j.pt.2020.07.017. Epub 2020 Aug 12.

RIFINing Plasmodium-NK Cell Interaction

Didier Ménard  1 , Sandrine Houzé  2 , Nicolas Papon  3
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RIFINing Plasmodium-NK Cell Interaction

Didier Ménard et al. Trends Parasitol. 2020 Oct.

Abstract

Among many Plasmodium proteins involved in the erythrocytic cycle, some exposed on the erythrocyte surface drive antigenic variability. Recently, Harrison et al. elucidated the structural basis by which RIFINs activate LILRB1 and suppress immune cell function. This breakthrough points to an additional strategy for survival in the human host.

Keywords: antigen variations; immune response inhibition; malaria; natural killers.

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