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Comment
. 2020 Sep;41(9):755-757.
doi: 10.1016/j.it.2020.07.012. Epub 2020 Aug 13.

A Gut Feeling about C9ORF72

Magdalini Polymenidou  1
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Comment

A Gut Feeling about C9ORF72

Magdalini Polymenidou. Trends Immunol. 2020 Sep.

Abstract

C9ORF72 mutations are the most common genetic cause of ALS and FTD, leading to neurodegeneration via complex mechanisms. Mutations also lead to loss of C9ORF72 function and inflammatory diseases in patients and knockout mice. Burberry et al. now show that C9orf72-associated inflammation and premature death in mice are directly modified by the gut microbiome.

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  • C9orf72 suppresses systemic and neural inflammation induced by gut bacteria.
    Burberry A, Wells MF, Limone F, Couto A, Smith KS, Keaney J, Gillet G, van Gastel N, Wang JY, Pietilainen O, Qian M, Eggan P, Cantrell C, Mok J, Kadiu I, Scadden DT, Eggan K. Burberry A, et al. Nature. 2020 Jun;582(7810):89-94. doi: 10.1038/s41586-020-2288-7. Epub 2020 May 13. Nature. 2020. PMID: 32483373 Free PMC article.

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