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. 1977 May 15;164(2):473-5.
doi: 10.1042/bj1640473.

The effects of antioxidants on the metabolism and mutagenicity of benzo[a]pyrene in vitro

A D Rahimtula, P K Zachariah, P J O'Brien

The effects of antioxidants on the metabolism and mutagenicity of benzo[a]pyrene in vitro

A D Rahimtula et al. Biochem J. .

Abstract

Antioxidants inhibit the rat liver microsomal mixed-function-oxidase-catalysed hydroxylation of benzo[a]pyrene. These antioxidants also decrease the formation of mutagenic products from benzo[a]pyrene as judged by the Ames bacterial-mutagenicity assay [B.N. Ames, J. McCann & E. Yamazaki (1975) Mutat. Res. 31, 347-364]. It is suggested that antioxidants exert their protective effect against cancer by inhibiting the formation of carcinogenic metabolites.

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