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. 2020 May 27;6(7):FSO596.
doi: 10.2144/fsoa-2020-0015.

A new standardized data collection system for brain stereotactic external radiotherapy: the PRE.M.I.S.E project

Silvia Chiesa  1 , Barbara Tolu  2 , Silvia Longo  3 , Barbara Nardiello  2 , Nikola Dino Capocchiano  3 , Federica Rea  2 , Luca Capone  2 , Gerardina Stimato  4 , Roberto Gatta  5 , Alessandro Pacchiarotti  1 , Mariangela Massaccesi  1 , Giuseppe Minniti  2 , Francesco Cellini  1 , Andrea Damiani  3 , Mario Balducci  1   3 , Piercarlo Gentile  2 , Vincenzo Valentini  1   3 , Federico Bianciardi  2
Affiliations

A new standardized data collection system for brain stereotactic external radiotherapy: the PRE.M.I.S.E project

Silvia Chiesa et al. Future Sci OA. .

Abstract

Background: In recent years, novel radiation therapy techniques have moved clinical practice toward tailored medicine. An essential role is played by the decision support system, which requires a standardization of data collection. The Aim of the Prediction Models In Stereotactic External radiotherapy (PRE.M.I.S.E.) project is the implementation of systems that analyze heterogeneous datasets. This article presents the project design, focusing on brain stereotactic radiotherapy (SRT).

Materials & methods: First, raw ontology was defined by exploiting semiformal languages (block and entity relationship diagrams) and the natural language; then, it was transposed in a Case Report Form, creating a storage system.

Results: More than 130 brain SRT's variables were selected. The dedicated software Beyond Ontology Awareness (BOA-Web) was set and data collection is ongoing.

Conclusion: The PRE.M.I.S.E. project provides standardized data collection for a specific radiation therapy technique, such as SRT. Future aims are: including other centers and validating an extracranial SRT ontology.

Keywords: big data; brain; personalized medicine; predictive model; stereotactic.

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Conflict of interest statement

Financial & competing interests disclosure The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in, or financial conflict, with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties. No writing assistance was utilized in the production of this manuscript.

Figures

Figure 1.
Figure 1.. Ontology structure in the SQLite database.
CRF: Case report form.
Figure 2.
Figure 2.. An example screenshot of a case report form.
CRF: Case report form.
Figure 3.
Figure 3.. general overview of how the Beyond Ontology Awareness service is laid out.
BOA: Beyond ontology awareness.
Figure 4.
Figure 4.. Distance between lesions, equating every lesion to an equivalent sphere.
See this image and copyright information in PMC

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