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Review
. 2020 Jul 15;8(7):e2869.
doi: 10.1097/GOX.0000000000002869. eCollection 2020 Jul.

Infectious Complications Associated with the Use of Integra: A Systematic Review of the Literature

Santiago R Gonzalez  1 , Keith G Wolter  2 , James C Yuen  2
Affiliations
Review

Infectious Complications Associated with the Use of Integra: A Systematic Review of the Literature

Santiago R Gonzalez et al. Plast Reconstr Surg Glob Open. .

Abstract

Dermal regeneration templates such as Integra are effective reconstructive biomaterials used in a variety of soft-tissue defects. Fully understanding the complications associated with their use is paramount to improve outcomes and maximize patient safety. In this study, our purpose is to perform a comprehensive literature review to assess the previously reported infectious complications linked to Integra-based wound closure.

Methods: We conducted a systematic review of the literature to identify previous articles indexed in PubMed and Ovid for Integra and its synonymous terms. We used these search terms: [Integra OR (dermal regenerative matrix) OR (dermal regeneration matrix) OR (dermal regenerative template) OR (dermal regeneration template) OR (dermal substitute) OR (skin substitute) OR (artificial skin)] AND infection.

Results: Of the 3508 articles for initial review, 69 reported rates of infection, of which 26 reported ≥1 infection within their cohort. Of these 26 articles, the patients (n = 602) underwent Integra-based reconstruction in 1254 sites and had reported infections in 212 of the sites (16.9%). Among these, we encountered a single report of a fatal case of toxic shock syndrome (TSS) related to the use of Integra in secondary burn reconstruction.

Conclusions: While Integra offers many benefits, surgeons must be aware that infectious complications are not uncommon. As a result, a careful risk-benefit analysis of its use in reconstruction must be performed, and open discussion with the patient preoperatively regarding infection rate is of utmost importance.

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Figures

Fig. 1.
Fig. 1.
Steps taken to perform the literature review to identify articles who report cases of infections as postoperative outcomes following skin reconstruction with Integra.
See this image and copyright information in PMC

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