Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Oct;140(4):587-589.
doi: 10.1007/s00401-020-02212-z. Epub 2020 Aug 14.

Brain pathologies are associated with both the rate and variability of declining motor function in older adults

Aron S Buchman  1   2 , Tianhao Wang  3   4 , Lei Yu  3   4 , Sue E Leurgans  3   4   5 , Julie A Schneider  3   4   6 , David A Bennett  3   4
Affiliations

Brain pathologies are associated with both the rate and variability of declining motor function in older adults

Aron S Buchman et al. Acta Neuropathol. 2020 Oct.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1. Associations of nigral neuronal loss with motor decline and motor variability.
1a contrasts the person-specific linear trajectories of global motor decline in adults with (light red lines) and without (light blue lines) moderate-severe nigral neuronal loss. 1b contrasts the fitted-person specific trajectories of global motor decline in adults with (light red lines) and without (light blue lines) moderate-severe nigral neuronal loss. The dark red and blue lines represent the average global motor decline for the entire group of participants with and without moderate-severe nigral neuronal loss. 1c contrasts global motor variability for adults with (light red lines) and without (light blue lines) moderate-severe nigral neuronal loss. The dark black line represents the annual decline of global motor score for all individuals.The dark red and blue lines represent the 95th percent confidence interval for global motor variability for individuals with and without moderate-severe nigral neuronal loss. The red lines are more widely displaced than the blue lines showing more variability.
See this image and copyright information in PMC

References

    1. Bennett DA, Buchman AS, Boyle PA, Barnes LL, Wilson RS, Schneider JA (2018) Religious Orders Study and Rush Memory and Aging Project. J Alzheimers Dis 64:S161–S189. doi:10.3233/jad-179939 - DOI - PMC - PubMed
    1. Buchman AS, Yu L, Oveisgharan S, Farfel JM, Schneider JA, Bennett DaA (2020) Person-specific contributions of brain pathologies to progressive parkinsonism in older adults. Journal Gerontology A Biological Science Medical Science, doi: 10.1093/gerona/glaa176; In press - DOI - PMC - PubMed
    1. Buchman AS, Yu L, Wilson RS, Leurgans SE, Nag S, Shulman JM, Barnes LL, Schneider JA, Bennett DA (2019) Progressive parkinsonism in older adults is related to the burden of mixed brain pathologies. Neurology 92:e1821–e1830. doi:10.1212/wnl.0000000000007315 - DOI - PMC - PubMed
    1. Schneider JA, Arvanitakis Z, Yu L, Boyle PA, Leurgans SE, Bennett DA (2012) Cognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodies. Brain 135:3005–3014. doi:10.1093/brain/aws234 - DOI - PMC - PubMed
    1. Selen LP, Beek PJ, van Dieen JH (2005) Can co-activation reduce kinematic variability? A simulation study. Biol Cybern 93:373–381. doi:10.1007/s00422-005-0015-y - DOI - PubMed

Publication types