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Meta-Analysis
. 2020 Nov;151(2):175-179.
doi: 10.1002/ijgo.13347. Epub 2020 Sep 16.

Long-term seizure recurrence after eclampsia: A systematic review and meta-analysis

Zoe E Barber  1 , Thomas D Dobbs  2   3 , John A G Gibson  2   3 , Monique Latibeaudiere  4 , Amy O Robb  4
Affiliations
Meta-Analysis

Long-term seizure recurrence after eclampsia: A systematic review and meta-analysis

Zoe E Barber et al. Int J Gynaecol Obstet. 2020 Nov.

Abstract

Background: Seizure recurrence after a fit has implications for both individuals and healthcare providers guiding neurologic prognosis, treatment, and driving and work restrictions. A systematic review of long-term seizure recurrence after eclampsia will help to quantify recurrence risk in this setting.

Objective: To evaluate the long-term recurrence of seizures after eclampsia.

Search strategy: After PROSPERO registration, Medline (Ovid), Embase, and Cochrane Library were searched by using the terms (eclampsia OR eclamp* OR eclamptic seizure* OR eclamptic fit*) AND (recur* OR recurrent fit* OR recurrent seizure*) for studies published up until December 2019.

Selection criteria: Studies describing long-term seizure recurrence after a diagnosis of eclampsia were included.

Data collection and analysis: Data were extracted from studies independently by two authors. Pooled prevalence was calculated and weighted based on sample size with a 95% confidence interval (CI).

Main results: Initially, 1754 unique studies were identified and 4 were included in the final analysis. The studies involved 1896 women, of whom 7 (0.37%) were affected by a further seizure. The weighted pooled prevalence of seizure recurrence was 0.18% (95% CI, 0.03-1.02).

Conclusion: The absolute rate of long-term seizure recurrence after eclampsia is extremely low and within safe limits for driving.

Keywords: Eclampsia; Recurrence risk; Seizures.

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References

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