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Review
. 2021 Feb;46(2):745-748.
doi: 10.1007/s00261-020-02703-3. Epub 2020 Aug 17.

What radiologists should know about microRNA (miRNA) serum biomarkers for germ cell tumors

Matthew A Morgan  1 , Joanie M Garratt  2 , David J Vaughn  3
Affiliations
Review

What radiologists should know about microRNA (miRNA) serum biomarkers for germ cell tumors

Matthew A Morgan et al. Abdom Radiol (NY). 2021 Feb.

Abstract

MicroRNAs expressed by germ cell tumors represent a novel approach to detection of metastatic disease during staging, surveillance, and recurrence post-therapy. It has particular promise in settings of equivocal imaging, such as clinical stage I GCT, tumor marker negative stage IIA, or after chemotherapy. These miRNAs have the potential to change typical serum marker evaluation and imaging surveillance schedules.

Keywords: Germ cell tumor; NSGCT; Seminoma; Testicle; Tumor marker.

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