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Editorial
. 2020 Aug 18;142(7):684-687.
doi: 10.1161/CIRCULATIONAHA.120.048655. Epub 2020 Aug 17.

Crosstalk Between the Heart and Cancer: Beyond Drug Toxicity

Javid Moslehi  1 , Qing Zhang  2 , Kathryn J Moore  3
Affiliations
Editorial

Crosstalk Between the Heart and Cancer: Beyond Drug Toxicity

Javid Moslehi et al. Circulation. .
No abstract available

Keywords: Editorials; cardiology; models, animal; neoplasms.

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Conflict of interest statement

Conflict of Interest/Disclosures

JM has served on advisory boards for Pfizer, Novartis, Bristol-Myers Squibb, Deciphera, Audentes Pharmaceuticals, Nektar, Ipsen, Takeda, Myokardia, AstraZeneca, TripleGene/Precisgen, Regeneron GlaxoSmithKline, Boston Biomedical, ImmunoCore, Janssen, and Myovant and is supported by R01 HL141466. QZ is a Cancer Prevention and Research Institute of Texas (CPRIT) Scholar and is supported by CPRIT (RR190058) and NCI R01CA211732. KJM is supported by the National Institutes of Health (R35HL135799 and P01HL131478).

Figures

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The world of cardio-oncology.
The intersection between cancer and cardiovascular disease extends beyond cancer and cancer treatment effects on the cardiovascular and cardiometabolic systems. There is a growing appreciation of common risk factors that predispose patients to both cancer and cardiovascular disease. Emerging data also suggest the concept of “reverse cardio-oncology” whereby heart disease potentiates cancer.
See this image and copyright information in PMC

Comment on

  • Early Cardiac Remodeling Promotes Tumor Growth and Metastasis.
    Avraham S, Abu-Sharki S, Shofti R, Haas T, Korin B, Kalfon R, Friedman T, Shiran A, Saliba W, Shaked Y, Aronheim A. Avraham S, et al. Circulation. 2020 Aug 18;142(7):670-683. doi: 10.1161/CIRCULATIONAHA.120.046471. Epub 2020 Jun 1. Circulation. 2020. PMID: 32475164

References

    1. Moslehi JJ. Cardiovascular Toxic Effects of Targeted Cancer Therapies. N Engl J Med. 2016;375:1457–1467. - PubMed
    1. Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N, Chavez A et al. Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med. 2014;371:2488–2498. - PMC - PubMed
    1. Meijers WC and de Boer RA. Common risk factors for heart failure and cancer. Cardiovasc Res. 2019;115:844–853. - PMC - PubMed
    1. Meijers WC, Maglione M, Bakker SJL, Oberhuber R, Kieneker LM, de Jong S, Haubner BJ, Nagengast WB, Lyon AR, van der Vegt B, et al. Heart Failure Stimulates Tumor Growth by Circulating Factors. Circulation. 2018;138:678–691. - PubMed
    1. Avraham S, Abu-Sharki S, Shofti R, Haas T, Korin B, Kalfon R, Friedman T, Shiran A, Saliba W, Shaked Y and Aronheim A. Early Cardiac Remodeling Promotes Tumor Growth and Metastasis. Circulation. 2020[In Press]. - PubMed

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