Widespread Metastatic Gastric Signet-Ring Cell Carcinoma Shown by 68Ga-FAPI PET/CT
- PMID: 32804764
- DOI: 10.1097/RLU.0000000000003245
Widespread Metastatic Gastric Signet-Ring Cell Carcinoma Shown by 68Ga-FAPI PET/CT
Abstract
The present study compared 68Ga-FAPI and 18F-FDG PET/CT in a patient with GSRCC (gastric signet-ring cell carcinoma). In this case, 68Ga-FAPI PET/CT shows much higher tumor-to-background contrast of primary tumor and reveals more metastatic lesions than 18F-FDG PET/CT. This case demonstrates that 68Ga-FAPI PET/CT outperforms 18F-FDG in identifying both primary and metastatic lesions in GSRCC.
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
Conflict of interest statement
Conflicts of interest and sources of funding: The authors declare no conflicts of interest. This work was supported by the National Natural Science Foundation of China (grant no. 81801735 and grant no. 81701736).
References
-
- Bhure U, Schmitt AM, Pestalozzi BC, et al. FDG-negative signet ring cell cancer of the stomach with FDG-positive skin metastases. Clin Nucl Med . 2007;32:226–228.
-
- Buyyounouski MK, Klump WJ, Konski A, et al. FDG PET imaging of signet-ring cell adenocarcinoma of the stomach. Clin Nucl Med . 2005;30:118–119.
-
- Yoshioka T, Yamaguchi K, Kubota K, et al. Evaluation of 18 F-FDG PET in patients with advanced, metastatic, or recurrent gastric cancer. J Nucl Med . 2003;44:690–699.
-
- Chen H, Pang Y, Wu J, et al. Comparison of [ 68 Ga]Ga-DOTA-FAPI-04 and [ 18 F] FDG PET/CT for the diagnosis of primary and metastatic lesions in patients with various types of cancer. Eur J Nucl Med Mol Imaging . 2020;47:1820–1832.
-
- Giesel FL, Kratochwil C, Lindner T, et al. 68 Ga-FAPI PET/CT: biodistribution and preliminary dosimetry estimate of 2 DOTA-containing FAP-targeting agents in patients with various cancers. J Nucl Med . 2019;60:386–392.
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